Kaposi's Sarcoma Associated Herpesvirus Tegument Protein ORF75 Is Essential for Viral Lytic Replication and Plays a Critical Role in the Antagonization of ND10-Instituted Intrinsic Immunity

Florian Full; Doris Jungnickl; Nina Reuter; Elke Bogner; Kevin Brulois; Brigitte Scholz; Michael Stürzl; Jinjong Myoung; Jae U. Jung; Thomas Stamminger; Armin Ensser

doi:10.1371/journal.ppat.1003863

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Open Access

Peer-reviewed

Research Article

Kaposi's Sarcoma Associated Herpesvirus Tegument Protein ORF75 Is Essential for Viral Lytic Replication and Plays a Critical Role in the Antagonization of ND10-Instituted Intrinsic Immunity

Florian Full,

Current address: Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America.

Affiliation Institute for Clinical and Molecular Virology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Doris Jungnickl,

Affiliation Institute for Clinical and Molecular Virology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Nina Reuter,

Affiliation Institute for Clinical and Molecular Virology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Elke Bogner,

Affiliation Institut für Medizinische Virologie, Charité-Universitätsmedizin Berlin, Berlin, Germany
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Kevin Brulois,

Affiliation Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯
Brigitte Scholz,

Affiliation Institute for Clinical and Molecular Virology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Michael Stürzl,

Affiliation Division of Molecular and Experimental Surgery, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Jinjong Myoung,

Current address: Korea Zoonosis Research Institute, Chonbuk National University Deokjin-dong 1ga, Deokjin-gu, Jeonju-si, Jeollabuk-do, Korea.

Affiliation Novartis Institutes for Biomedical Research, Emeryville, California, United States of America
⨯
Jae U. Jung,

Affiliation Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯
Thomas Stamminger,

Affiliation Institute for Clinical and Molecular Virology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Armin Ensser

* E-mail: armin.ensser@viro.med.uni-erlangen.de

Affiliation Institute for Clinical and Molecular Virology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⨯

Kaposi's Sarcoma Associated Herpesvirus Tegument Protein ORF75 Is Essential for Viral Lytic Replication and Plays a Critical Role in the Antagonization of ND10-Instituted Intrinsic Immunity

Florian Full,
Doris Jungnickl,
Nina Reuter,
Elke Bogner,
Kevin Brulois,
Brigitte Scholz,
Michael Stürzl,
Jinjong Myoung,
Jae U. Jung,
Thomas Stamminger

Published: January 16, 2014
https://doi.org/10.1371/journal.ppat.1003863

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Viral replication
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Kaposi's sarcoma-associated herpesvirus
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Herpesviruses
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Transfection
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Virions
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DNA recombination
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DNA replication
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Tegument proteins
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