DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway

Su-Yu Tsai; Jesus A. Segovia; Te-Hung Chang; Ian R. Morris; Michael T. Berton; Philippe A. Tessier; Mélanie R. Tardif; Annabelle Cesaro; Santanu Bose

doi:10.1371/journal.ppat.1003848

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Open Access

Peer-reviewed

Research Article

DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway

Su-Yu Tsai,

Affiliation Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Jesus A. Segovia,

Affiliation Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Te-Hung Chang,

Affiliation Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Ian R. Morris,

Affiliation Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Michael T. Berton,

Affiliation Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Philippe A. Tessier,

Affiliation Axe Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec, and Faculté de Médecine, Université Laval, Quebec, Canada
⨯
Mélanie R. Tardif,

Affiliation Axe Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec, and Faculté de Médecine, Université Laval, Quebec, Canada
⨯
Annabelle Cesaro,

Affiliation Axe Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec, and Faculté de Médecine, Université Laval, Quebec, Canada
⨯
Santanu Bose

* E-mail: bose@uthscsa.edu

Affiliation Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯

DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway

Su-Yu Tsai,
Jesus A. Segovia,
Te-Hung Chang,
Ian R. Morris,
Michael T. Berton,
Philippe A. Tessier,
Mélanie R. Tardif,
Annabelle Cesaro,
Santanu Bose

Published: January 2, 2014
https://doi.org/10.1371/journal.ppat.1003848

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