HIV-1 Vpr Accelerates Viral Replication during Acute Infection by Exploitation of Proliferating CD4⁺ T Cells In Vivo

• Kei Sato ,

  * E-mail: ksato@virus.kyoto-u.ac.jp (KS); ykoyanag@virus.kyoto-u.ac.jp (YK)

  Affiliations Laboratory of Virus Pathogenesis, Institute for Virus Research, Kyoto University, Kyoto, Kyoto, Japan, Center for Emerging Virus Research, Institute for Virus Research, Kyoto University, Kyoto, Kyoto, Japan

  ⨯
• Naoko Misawa,

  Affiliation Laboratory of Virus Pathogenesis, Institute for Virus Research, Kyoto University, Kyoto, Kyoto, Japan

  ⨯
• Shingo Iwami,

  Affiliations Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Fukuoka, Japan, Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), Kawaguchi, Saitama, Japan

  ⨯
• Yorifumi Satou,

  Affiliation Laboratory of Viral Control, Institute for Virus Research, Kyoto University, Kyoto, Kyoto, Japan

  ⨯
• Masao Matsuoka,

  Affiliation Laboratory of Viral Control, Institute for Virus Research, Kyoto University, Kyoto, Kyoto, Japan

  ⨯
• Yukihito Ishizaka,

  Affiliation Department of Intractable Diseases, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan

  ⨯
• Mamoru Ito,

  Affiliation Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan

  ⨯
• Kazuyuki Aihara,

  Affiliations Institute of Industrial Science, The University of Tokyo, Meguro-ku, Tokyo, Japan, Graduate School of Information Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

  ⨯
• Dong Sung An,

  Affiliations Division of Hematology-Oncology, University of California, Los Angeles (UCLA), Los Angeles, California, United States of America, School of Nursing, UCLA, Los Angeles, California, United States of America, AIDS Institute, UCLA, Los Angeles, California, United States of America

  ⨯
• Yoshio Koyanagi

  * E-mail: ksato@virus.kyoto-u.ac.jp (KS); ykoyanag@virus.kyoto-u.ac.jp (YK)

  Affiliations Laboratory of Virus Pathogenesis, Institute for Virus Research, Kyoto University, Kyoto, Kyoto, Japan, Center for Emerging Virus Research, Institute for Virus Research, Kyoto University, Kyoto, Kyoto, Japan

  ⨯