The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

• Devin Sok ,

  Contributed equally to this work with: Devin Sok, Uri Laserson, Jonathan Laserson, Yi Liu

  Affiliations Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America

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• Uri Laserson ,

  Contributed equally to this work with: Devin Sok, Uri Laserson, Jonathan Laserson, Yi Liu

  Affiliations Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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• Jonathan Laserson ,

  Contributed equally to this work with: Devin Sok, Uri Laserson, Jonathan Laserson, Yi Liu

  Affiliation Department of Computer Science, Stanford University, Stanford, California, United States of America

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• Yi Liu ,

  Contributed equally to this work with: Devin Sok, Uri Laserson, Jonathan Laserson, Yi Liu

  Affiliations Department of Computer Science, Stanford University, Stanford, California, United States of America, Biomedical Informatics Training Program, Stanford University School of Medicine, Stanford, California, United States of America

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• Francois Vigneault,

  Affiliations Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, AbVitro Inc., Boston, Massachusetts, United States of America

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• Jean-Philippe Julien,

  Affiliations IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• Bryan Briney,

  Affiliations Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America

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• Alejandra Ramos,

  Affiliations Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America, International AIDS Vaccine Initiative, New York, New York, United States of America

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• Karen F. Saye,

  Affiliations Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America

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• Khoa Le,

  Affiliations Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America

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• Alison Mahan,

  Affiliation Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, Massachusetts, United States of America

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• Shenshen Wang,

  Affiliations Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Mehran Kardar,

  Affiliation Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Gur Yaari,

  Affiliation Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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• Laura M. Walker,

  Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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• Birgitte B. Simen,

  Affiliation 454 Life Sciences – A Roche Company, Branford, Connecticut, United States of America

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• Elizabeth P. St. John,

  Affiliation 454 Life Sciences – A Roche Company, Branford, Connecticut, United States of America

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• Po-Ying Chan-Hui,

  Affiliation Theraclone Sciences, Inc., Seattle, Washington, United States of America

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• Kristine Swiderek,

  Affiliation Theraclone Sciences, Inc., Seattle, Washington, United States of America

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• Stephen H. Kleinstein,

  Affiliation Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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• Galit Alter,

  Affiliation Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, Massachusetts, United States of America

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• Michael S. Seaman,

  Affiliation Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

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• Arup K. Chakraborty,

  Affiliations Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, Massachusetts, United States of America, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Chemistry, Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Daphne Koller,

  Affiliation Department of Computer Science, Stanford University, Stanford, California, United States of America

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• Ian A. Wilson,

  Affiliations IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• George M. Church,

  Affiliations Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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• Dennis R. Burton ,

  * E-mail: burton@scripps.edu

  Affiliations Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, Massachusetts, United States of America

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•  [ ... ],
• Pascal Poignard

  Affiliations Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, International AIDS Vaccine Initiative, New York, New York, United States of America

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