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Open Access
Peer-reviewed
Research Article
Turning Defense into Offense: Defensin Mimetics as Novel Antibiotics Targeting Lipid II
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Kristen M. Varney ,
Contributed equally to this work with: Kristen M. Varney, Alexandre M. J. J. Bonvin, Marzena Pazgier, Jakob Malin, Wenbo Yu
Affiliation NMR Facility, University of Maryland Baltimore School of Medicine, Baltimore, Maryland, United States of America
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Alexandre M. J. J. Bonvin ,
Contributed equally to this work with: Kristen M. Varney, Alexandre M. J. J. Bonvin, Marzena Pazgier, Jakob Malin, Wenbo Yu
Affiliation Utrecht University, Bijvoet Center for Biomolecular Research, Faculty of Science-Chemistry, Utrecht, The Netherlands
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Marzena Pazgier ,
Contributed equally to this work with: Kristen M. Varney, Alexandre M. J. J. Bonvin, Marzena Pazgier, Jakob Malin, Wenbo Yu
Affiliation Institute of Human Virology & Department of Biochemistry and Molecular Biology of the University of Maryland Baltimore School of Medicine, Baltimore, Maryland, United States of America
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Jakob Malin ,
Contributed equally to this work with: Kristen M. Varney, Alexandre M. J. J. Bonvin, Marzena Pazgier, Jakob Malin, Wenbo Yu
Affiliation Maastricht University Medical Center, Maastricht, The Netherlands
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Wenbo Yu ,
Contributed equally to this work with: Kristen M. Varney, Alexandre M. J. J. Bonvin, Marzena Pazgier, Jakob Malin, Wenbo Yu
Affiliation Department of Pharmaceutical Sciences and Computer-Aided Drug Design Center, University of Maryland, School of Pharmacy, Baltimore, Maryland, United States of America
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Eugene Ateh,
Affiliation Institute of Human Virology & Department of Biochemistry and Molecular Biology of the University of Maryland Baltimore School of Medicine, Baltimore, Maryland, United States of America
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Taiji Oashi,
Affiliation Department of Pharmaceutical Sciences and Computer-Aided Drug Design Center, University of Maryland, School of Pharmacy, Baltimore, Maryland, United States of America
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Wuyuan Lu,
Affiliation Institute of Human Virology & Department of Biochemistry and Molecular Biology of the University of Maryland Baltimore School of Medicine, Baltimore, Maryland, United States of America
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Jing Huang,
Affiliation Department of Pharmaceutical Sciences and Computer-Aided Drug Design Center, University of Maryland, School of Pharmacy, Baltimore, Maryland, United States of America
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Marlies Diepeveen-de Buin,
Affiliation Utrecht University, Bijvoet Center for Biomolecular Research, Faculty of Science-Chemistry, Utrecht, The Netherlands
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Joseph Bryant,
Affiliation Institute of Human Virology & Department of Biochemistry and Molecular Biology of the University of Maryland Baltimore School of Medicine, Baltimore, Maryland, United States of America
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Eefjan Breukink,
Affiliation Utrecht University, Bijvoet Center for Biomolecular Research, Faculty of Science-Chemistry, Utrecht, The Netherlands
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Alexander D. MacKerell Jr,
Affiliation Department of Pharmaceutical Sciences and Computer-Aided Drug Design Center, University of Maryland, School of Pharmacy, Baltimore, Maryland, United States of America
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Erik P. H. de Leeuw
* E-mail: edeleeuw@som.umaryland.edu
Affiliation Institute of Human Virology & Department of Biochemistry and Molecular Biology of the University of Maryland Baltimore School of Medicine, Baltimore, Maryland, United States of America
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Turning Defense into Offense: Defensin Mimetics as Novel Antibiotics Targeting Lipid II
- Kristen M. Varney,
- Alexandre M. J. J. Bonvin,
- Marzena Pazgier,
- Jakob Malin,
- Wenbo Yu,
- Eugene Ateh,
- Taiji Oashi,
- Wuyuan Lu,
- Jing Huang,
- Marlies Diepeveen-de Buin
- Published: November 7, 2013
- https://doi.org/10.1371/journal.ppat.1003732