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Open Access
Peer-reviewed
Research Article
A Trypanosoma brucei Kinesin Heavy Chain Promotes Parasite Growth by Triggering Host Arginase Activity
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Géraldine De Muylder,
Affiliation Laboratory of Molecular Parasitology, IBMM, Université Libre de Bruxelles (ULB), Gosselies, Belgium
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Sylvie Daulouède,
Affiliation Laboratoire de Parasitologie, UMR 177 IRD CIRAD Université de Bordeaux, Bordeaux, France
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Laurence Lecordier,
Affiliation Laboratory of Molecular Parasitology, IBMM, Université Libre de Bruxelles (ULB), Gosselies, Belgium
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Pierrick Uzureau,
Affiliation Laboratory of Molecular Parasitology, IBMM, Université Libre de Bruxelles (ULB), Gosselies, Belgium
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Yannick Morias,
Affiliations Myeloid Cell Immunology Laboratory, VIB Brussels, Brussels, Belgium, Cellular and Molecular Immunology Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium
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Jan Van Den Abbeele,
Affiliation Department of Biomedical Sciences, Veterinary Protozoology Unit, Prins Leopold Institute of Tropical Medicine Antwerp, Antwerp, Belgium
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Guy Caljon,
Affiliations Myeloid Cell Immunology Laboratory, VIB Brussels, Brussels, Belgium, Cellular and Molecular Immunology Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium, Department of Biomedical Sciences, Veterinary Protozoology Unit, Prins Leopold Institute of Tropical Medicine Antwerp, Antwerp, Belgium
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Michel Hérin,
Affiliation Department of Pathology, Institut de Pathologie et de Génétique, Gosselies, Belgium
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Philippe Holzmuller,
Affiliation Laboratoire de Parasitologie, UMR 177 IRD CIRAD Université de Bordeaux, Bordeaux, France
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Silla Semballa,
Affiliation Laboratoire de Parasitologie, UMR 177 IRD CIRAD Université de Bordeaux, Bordeaux, France
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Pierrette Courtois,
Affiliation Laboratoire de Parasitologie, UMR 177 IRD CIRAD Université de Bordeaux, Bordeaux, France
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Luc Vanhamme,
Affiliation Laboratory of Molecular Parasitology, IBMM, Université Libre de Bruxelles (ULB), Gosselies, Belgium
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Benoît Stijlemans,
Affiliations Myeloid Cell Immunology Laboratory, VIB Brussels, Brussels, Belgium, Cellular and Molecular Immunology Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium
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Patrick De Baetselier,
Affiliations Myeloid Cell Immunology Laboratory, VIB Brussels, Brussels, Belgium, Cellular and Molecular Immunology Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium
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Michael P. Barrett,
Affiliations The Wellcome Trust Centre for Molecular Parasitology, Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Glasgow Polyomics Facility, University of Glasgow, Glasgow, United Kingdom
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Jillian L. Barlow,
Affiliation Laboratory of Molecular Biology, Medical Research Council, Cambridge, United Kingdom
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Andrew N. J. McKenzie,
Affiliation Laboratory of Molecular Biology, Medical Research Council, Cambridge, United Kingdom
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Luke Barron,
Affiliation Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Thomas A. Wynn,
Affiliation Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Alain Beschin ,
* E-mail: abeschin@ulb.ac.be
¶AB, PV and EP are co-senior authors on this work.
Affiliations Laboratory of Molecular Parasitology, IBMM, Université Libre de Bruxelles (ULB), Gosselies, Belgium, Myeloid Cell Immunology Laboratory, VIB Brussels, Brussels, Belgium, Cellular and Molecular Immunology Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium
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Philippe Vincendeau ,
¶AB, PV and EP are co-senior authors on this work.
Affiliation Laboratoire de Parasitologie, UMR 177 IRD CIRAD Université de Bordeaux, Bordeaux, France
⨯ - [ ... ],
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Etienne Pays
¶AB, PV and EP are co-senior authors on this work.
Affiliation Laboratory of Molecular Parasitology, IBMM, Université Libre de Bruxelles (ULB), Gosselies, Belgium
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A Trypanosoma brucei Kinesin Heavy Chain Promotes Parasite Growth by Triggering Host Arginase Activity
- Géraldine De Muylder,
- Sylvie Daulouède,
- Laurence Lecordier,
- Pierrick Uzureau,
- Yannick Morias,
- Jan Van Den Abbeele,
- Guy Caljon,
- Michel Hérin,
- Philippe Holzmuller,
- Silla Semballa
- Published: October 31, 2013
- https://doi.org/10.1371/journal.ppat.1003731