Deletion of the α-(1,3)-Glucan Synthase Genes Induces a Restructuring of the Conidial Cell Wall Responsible for the Avirulence of Aspergillus fumigatus

Anne Beauvais; Silvia Bozza; Olaf Kniemeyer; Céline Formosa; Viviane Balloy; Christine Henry; Robert W. Roberson; Etienne Dague; Michel Chignard; Axel A. Brakhage; Luigina Romani; Jean-Paul Latgé

doi:10.1371/journal.ppat.1003716

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Peer-reviewed

Research Article

Deletion of the α-(1,3)-Glucan Synthase Genes Induces a Restructuring of the Conidial Cell Wall Responsible for the Avirulence of Aspergillus fumigatus

Anne Beauvais ,

* E-mail: anne.beauvais@pasteur.fr

Affiliation Unité des Aspergillus, Institut Pasteur, Paris, France
⨯
Silvia Bozza,

Affiliation Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
⨯
Olaf Kniemeyer,

Affiliations Molecular and Applied Microbiology, Leibniz-Institute for Natural Product Research and Infection Biology (HKI), University of Jena, Jena, Germany, Integrated Research and Treatment Center, Center for Sepsis Control and Care Jena, University Hospital (CSCC), Jena, Germany
⨯
Céline Formosa,

Affiliation CNRS, LAAS, Toulouse, France
⨯
Viviane Balloy,

Affiliation Unité de Défence Innée et Inflammation, Institut Pasteur, Inserm U874, Paris, France
⨯
Christine Henry,

Affiliation Unité des Aspergillus, Institut Pasteur, Paris, France
⨯
Robert W. Roberson,

Affiliation School of Life Sciences, Arizona State University, Tempe, Arizona, United States of America
⨯
Etienne Dague,

Affiliation CNRS, LAAS, Toulouse, France
⨯
Michel Chignard,

Affiliation Unité de Défence Innée et Inflammation, Institut Pasteur, Inserm U874, Paris, France
⨯
Axel A. Brakhage,

Affiliation Molecular and Applied Microbiology, Leibniz-Institute for Natural Product Research and Infection Biology (HKI), University of Jena, Jena, Germany
⨯
Luigina Romani,

Affiliation Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
⨯
Jean-Paul Latgé

Affiliation Unité des Aspergillus, Institut Pasteur, Paris, France
⨯

Deletion of the α-(1,3)-Glucan Synthase Genes Induces a Restructuring of the Conidial Cell Wall Responsible for the Avirulence of Aspergillus fumigatus

Anne Beauvais,
Silvia Bozza,
Olaf Kniemeyer,
Céline Formosa,
Viviane Balloy,
Christine Henry,
Robert W. Roberson,
Etienne Dague,
Michel Chignard,
Axel A. Brakhage

Published: November 14, 2013
https://doi.org/10.1371/journal.ppat.1003716

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Cell walls
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Macrophages
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Aspergillus fumigatus
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