ZASC1 Stimulates HIV-1 Transcription Elongation by Recruiting P-TEFb and TAT to the LTR Promoter

James W. Bruce; Rachel Reddington; Elizabeth Mathieu; Megan Bracken; John A. T. Young; Paul Ahlquist

doi:10.1371/journal.ppat.1003712

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Research Article

ZASC1 Stimulates HIV-1 Transcription Elongation by Recruiting P-TEFb and TAT to the LTR Promoter

James W. Bruce,

Affiliations Morgridge Institute for Research, Madison, Wisconsin, United States of America, Institute for Molecular Virology, University of Wisconsin, Madison, Wisconsin, United States of America, McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin, United States of America
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Rachel Reddington,

Affiliations Morgridge Institute for Research, Madison, Wisconsin, United States of America, Institute for Molecular Virology, University of Wisconsin, Madison, Wisconsin, United States of America, Howard Hughes Medical Institute, University of Wisconsin, Madison, Wisconsin, United States of America
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Elizabeth Mathieu,

Affiliations Morgridge Institute for Research, Madison, Wisconsin, United States of America, Institute for Molecular Virology, University of Wisconsin, Madison, Wisconsin, United States of America
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Megan Bracken,

Affiliations Morgridge Institute for Research, Madison, Wisconsin, United States of America, Institute for Molecular Virology, University of Wisconsin, Madison, Wisconsin, United States of America
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John A. T. Young,

Affiliation Nomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, California, United States of America
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Paul Ahlquist

* E-mail: ahlquist@wisc.edu

Affiliations Morgridge Institute for Research, Madison, Wisconsin, United States of America, Institute for Molecular Virology, University of Wisconsin, Madison, Wisconsin, United States of America, McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin, United States of America, Howard Hughes Medical Institute, University of Wisconsin, Madison, Wisconsin, United States of America
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ZASC1 Stimulates HIV-1 Transcription Elongation by Recruiting P-TEFb and TAT to the LTR Promoter

James W. Bruce,
Rachel Reddington,
Elizabeth Mathieu,
Megan Bracken,
John A. T. Young,
Paul Ahlquist

Published: October 24, 2013
https://doi.org/10.1371/journal.ppat.1003712

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HIV-1
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T cells
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Transfection
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Plasmid construction
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DNA transcription
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Gene expression
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Luciferase
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Transcriptional control
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