Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity

Kwangkook Lee; Shenyan Gu; Lei Jin; Thi Tuc Nghi Le; Luisa W. Cheng; Jasmin Strotmeier; Anna Magdalena Kruel; Guorui Yao; Kay Perry; Andreas Rummel; Rongsheng Jin

doi:10.1371/journal.ppat.1003690

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Open Access

Peer-reviewed

Research Article

Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity

Kwangkook Lee ,

Contributed equally to this work with: Kwangkook Lee, Shenyan Gu

Affiliation Department of Physiology and Biophysics, University of California, Irvine, California, United States of America
⨯
Shenyan Gu ,

Contributed equally to this work with: Kwangkook Lee, Shenyan Gu

Affiliation Department of Physiology and Biophysics, University of California, Irvine, California, United States of America
⨯
Lei Jin,

Affiliation Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
⨯
Thi Tuc Nghi Le,

Affiliation Institut für Toxikologie, Medizinische Hochschule Hannover, Hannover, Germany
⨯
Luisa W. Cheng,

Affiliation Foodborne Contaminants Research Unit, Western Regional Research Center, United States Department of Agriculture, Agricultural Research Service, Albany, California, United States of America
⨯
Jasmin Strotmeier,

Affiliation Institut für Toxikologie, Medizinische Hochschule Hannover, Hannover, Germany
⨯
Anna Magdalena Kruel,

Affiliation Institut für Toxikologie, Medizinische Hochschule Hannover, Hannover, Germany
⨯
Guorui Yao,

Affiliation Department of Physiology and Biophysics, University of California, Irvine, California, United States of America
⨯
Kay Perry,

Affiliation NE-CAT and Department of Chemistry and Chemical Biology, Cornell University, Argonne National Laboratory, Argonne, Illinois, United States of America
⨯
Andreas Rummel ,

* E-mail: rummel.andreas@mh-hannover.de (AR); r.jin@uci.edu (RJ)

Affiliation Institut für Toxikologie, Medizinische Hochschule Hannover, Hannover, Germany
⨯
Rongsheng Jin

* E-mail: rummel.andreas@mh-hannover.de (AR); r.jin@uci.edu (RJ)

Affiliations Department of Physiology and Biophysics, University of California, Irvine, California, United States of America, Neuroscience, Aging and Stem Cell Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
⨯

Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity

Kwangkook Lee,
Shenyan Gu,
Lei Jin,
Thi Tuc Nghi Le,
Luisa W. Cheng,
Jasmin Strotmeier,
Anna Magdalena Kruel,
Guorui Yao,
Kay Perry,
Andreas Rummel

Published: October 10, 2013
https://doi.org/10.1371/journal.ppat.1003690

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Crystal structure
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Botulinum toxin
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