Type I Interferon Upregulates Bak and Contributes to T Cell Loss during Human Immunodeficiency Virus (HIV) Infection

Joseph A. Fraietta; Yvonne M. Mueller; Guibin Yang; Alina C. Boesteanu; Donald T. Gracias; Duc H. Do; Jennifer L. Hope; Noshin Kathuria; Shannon E. McGettigan; Mark G. Lewis; Luis D. Giavedoni; Jeffrey M. Jacobson; Peter D. Katsikis

doi:10.1371/journal.ppat.1003658

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Open Access

Peer-reviewed

Research Article

Type I Interferon Upregulates Bak and Contributes to T Cell Loss during Human Immunodeficiency Virus (HIV) Infection

Joseph A. Fraietta,

Affiliation Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Yvonne M. Mueller,

Affiliation Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Guibin Yang,

Affiliation Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Alina C. Boesteanu,

Affiliation Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Donald T. Gracias,

Affiliation Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Duc H. Do,

Affiliation Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Jennifer L. Hope,

Affiliation Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Noshin Kathuria,

Affiliation Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Shannon E. McGettigan,

Affiliation Translational Research Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Mark G. Lewis,

Affiliation BIOQUAL, Inc., Rockville, Maryland, United States of America
⨯
Luis D. Giavedoni,

Affiliation Departments of Virology and Immunology, Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
⨯
Jeffrey M. Jacobson,

Affiliation Department of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Peter D. Katsikis

* E-mail: peter.katsikis@drexelmed.edu

Affiliation Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Type I Interferon Upregulates Bak and Contributes to T Cell Loss during Human Immunodeficiency Virus (HIV) Infection

Joseph A. Fraietta,
Yvonne M. Mueller,
Guibin Yang,
Alina C. Boesteanu,
Donald T. Gracias,
Duc H. Do,
Jennifer L. Hope,
Noshin Kathuria,
Shannon E. McGettigan,
Mark G. Lewis

Published: October 10, 2013
https://doi.org/10.1371/journal.ppat.1003658

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