A Structural Basis for BRD2/4-Mediated Host Chromatin Interaction and Oligomer Assembly of Kaposi Sarcoma-Associated Herpesvirus and Murine Gammaherpesvirus LANA Proteins

Jan Hellert; Magdalena Weidner-Glunde; Joern Krausze; Ulrike Richter; Heiko Adler; Roman Fedorov; Marcel Pietrek; Jessica Rückert; Christiane Ritter; Thomas F. Schulz; Thorsten Lührs

doi:10.1371/journal.ppat.1003640

Open Access

Peer-reviewed

Research Article

A Structural Basis for BRD2/4-Mediated Host Chromatin Interaction and Oligomer Assembly of Kaposi Sarcoma-Associated Herpesvirus and Murine Gammaherpesvirus LANA Proteins

Jan Hellert ,

Contributed equally to this work with: Jan Hellert, Magdalena Weidner-Glunde

Affiliation Department of Structural Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany
⨯
Magdalena Weidner-Glunde ,

Contributed equally to this work with: Jan Hellert, Magdalena Weidner-Glunde

Affiliation Institute of Virology, Hannover Medical School, Hannover, Germany
⨯
Joern Krausze,

Affiliation Department of Structural Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany
⨯
Ulrike Richter,

Affiliation Institute of Virology, Hannover Medical School, Hannover, Germany
⨯
Heiko Adler,

Affiliation Research Unit Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Munich, Germany
⨯
Roman Fedorov,

Affiliations Research Division for Structural Analysis, Hannover Medical School, Hannover, Germany, Institute of Biophysical Chemistry, Hannover Medical School, Hannover, Germany
⨯
Marcel Pietrek,

Affiliation Institute of Virology, Hannover Medical School, Hannover, Germany
⨯
Jessica Rückert,

Affiliation Institute of Virology, Hannover Medical School, Hannover, Germany
⨯
Christiane Ritter,

Affiliation Department of Structural Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany
⨯
Thomas F. Schulz ,

* E-mail: Schulz.thomas@mh-hannover.de (TFS); Thorsten.Luehrs@helmholtz-hzi.de (TL)

Affiliation Institute of Virology, Hannover Medical School, Hannover, Germany
⨯
Thorsten Lührs

* E-mail: Schulz.thomas@mh-hannover.de (TFS); Thorsten.Luehrs@helmholtz-hzi.de (TL)

Affiliation Department of Structural Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany
⨯

A Structural Basis for BRD2/4-Mediated Host Chromatin Interaction and Oligomer Assembly of Kaposi Sarcoma-Associated Herpesvirus and Murine Gammaherpesvirus LANA Proteins

Jan Hellert, …
Magdalena Weidner-Glunde,
Joern Krausze,
Ulrike Richter,
Heiko Adler,
Roman Fedorov,
Marcel Pietrek,
Jessica Rückert,
Christiane Ritter,
Thomas F. Schulz

Published: October 17, 2013
https://doi.org/10.1371/journal.ppat.1003640

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