Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10

Kathryn A. K. Finton; Kevin Larimore; H. Benjamin Larman; Della Friend; Colin Correnti; Peter B. Rupert; Stephen J. Elledge; Philip D. Greenberg; Roland K. Strong

doi:10.1371/journal.ppat.1003639

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Peer-reviewed

Research Article

Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10

Kathryn A. K. Finton,

Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Kevin Larimore,

Affiliation Program in Immunology, Cancer Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
H. Benjamin Larman,

Affiliation Department of Genetics, Harvard University Medical School, and Division of Genetics, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
⨯
Della Friend,

Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Colin Correnti,

Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Peter B. Rupert,

Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Stephen J. Elledge,

Affiliation Department of Genetics, Harvard University Medical School, and Division of Genetics, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
⨯
Philip D. Greenberg,

Affiliations Program in Immunology, Cancer Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Immunology, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America
⨯
Roland K. Strong

* E-mail: rstrong@fhcrc.org

Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯

Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10

Kathryn A. K. Finton,
Kevin Larimore,
H. Benjamin Larman,
Della Friend,
Colin Correnti,
Peter B. Rupert,
Stephen J. Elledge,
Philip D. Greenberg,
Roland K. Strong

Published: September 26, 2013
https://doi.org/10.1371/journal.ppat.1003639

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