Alpha-Interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of cccDNA Minichromosomes

Fei Liu; Matthew Campagna; Yonghe Qi; Xuesen Zhao; Fang Guo; Chunxiao Xu; Sichen Li; Wenhui Li; Timothy M. Block; Jinhong Chang; Ju-Tao Guo

doi:10.1371/journal.ppat.1003613

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Open Access

Peer-reviewed

Research Article

Alpha-Interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of cccDNA Minichromosomes

Fei Liu,

Affiliation Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America
⨯
Matthew Campagna,

Affiliations Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America, Institute for Hepatitis and Virology Research, Hepatitis B Foundation, Doylestown, Pennsylvania, United States of America
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Yonghe Qi,

Affiliation National Institute of Biological Sciences, Beijing, People's Republic of China
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Xuesen Zhao,

Affiliation Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America
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Fang Guo,

Affiliation Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America
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Chunxiao Xu,

Affiliation Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America
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Sichen Li,

Affiliation Neurology Department, David Geffen Medical School, University of Los Angeles, Los Angeles, California, United States of America
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Wenhui Li,

Affiliation National Institute of Biological Sciences, Beijing, People's Republic of China
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Timothy M. Block,

Affiliations Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America, Institute for Hepatitis and Virology Research, Hepatitis B Foundation, Doylestown, Pennsylvania, United States of America
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Jinhong Chang,

Affiliation Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America
⨯
Ju-Tao Guo

* E-mail: Ju-Tao.Guo@drexelmed.edu

Affiliation Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America
⨯

Alpha-Interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of cccDNA Minichromosomes

Fei Liu,
Matthew Campagna,
Yonghe Qi,
Xuesen Zhao,
Fang Guo,
Chunxiao Xu,
Sichen Li,
Wenhui Li,
Timothy M. Block,
Jinhong Chang

Published: September 12, 2013
https://doi.org/10.1371/journal.ppat.1003613

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Circular DNA
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DNA transcription
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