Post-Translational Control of IL-1β via the Human Papillomavirus Type 16 E6 Oncoprotein: A Novel Mechanism of Innate Immune Escape Mediated by the E3-Ubiquitin Ligase E6-AP and p53

Martina Niebler; Xu Qian; Daniela Höfler; Vlada Kogosov; Jittranan Kaewprag; Andreas M. Kaufmann; Regina Ly; Gerd Böhmer; Rainer Zawatzky; Frank Rösl; Bladimiro Rincon-Orozco

doi:10.1371/journal.ppat.1003536

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Open Access

Peer-reviewed

Research Article

Post-Translational Control of IL-1β via the Human Papillomavirus Type 16 E6 Oncoprotein: A Novel Mechanism of Innate Immune Escape Mediated by the E3-Ubiquitin Ligase E6-AP and p53

Martina Niebler,

Affiliation Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Xu Qian,

Affiliation Gynecological Tumor-Immunology, Charité Campus Benjamin Franklin, Berlin, Germany
⨯
Daniela Höfler,

Affiliation Division of Genome Modifications and Carcinogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Vlada Kogosov,

Affiliation Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Jittranan Kaewprag,

Affiliations Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany, Molecular Medicine Program, Faculty of Science, Mahidol University, Bangkok, Thailand
⨯
Andreas M. Kaufmann,

Affiliation Gynecological Tumor-Immunology, Charité Campus Benjamin Franklin, Berlin, Germany
⨯
Regina Ly,

Affiliation Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Gerd Böhmer,

Affiliation Deutsche Klinik Bad Münder, Hannover, Germany
⨯
Rainer Zawatzky,

Affiliation Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Frank Rösl ,

* E-mail: f.roesl@dkfz.de (FR); blrincon@gmail.com (BRO)

Affiliation Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Bladimiro Rincon-Orozco

* E-mail: f.roesl@dkfz.de (FR); blrincon@gmail.com (BRO)

Affiliation Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯

Post-Translational Control of IL-1β via the Human Papillomavirus Type 16 E6 Oncoprotein: A Novel Mechanism of Innate Immune Escape Mediated by the E3-Ubiquitin Ligase E6-AP and p53

Martina Niebler,
Xu Qian,
Daniela Höfler,
Vlada Kogosov,
Jittranan Kaewprag,
Andreas M. Kaufmann,
Regina Ly,
Gerd Böhmer,
Rainer Zawatzky,
Frank Rösl

Published: August 1, 2013
https://doi.org/10.1371/journal.ppat.1003536

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