Blocking TLR7- and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection

Muhamuda Kader; Amanda P. Smith; Cristiana Guiducci; Elizabeth R. Wonderlich; Daniel Normolle; Simon C. Watkins; Franck J. Barrat; Simon M. Barratt-Boyes

doi:10.1371/journal.ppat.1003530

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Peer-reviewed

Research Article

Blocking TLR7- and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection

Muhamuda Kader,

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Amanda P. Smith,

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Cristiana Guiducci,

Affiliation Dynavax Technologies Corporation, Berkeley, California, United States of America
⨯
Elizabeth R. Wonderlich,

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Daniel Normolle,

Affiliation Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Simon C. Watkins,

Affiliation Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Franck J. Barrat,

Current address: Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, New York, United States of America.

Affiliation Dynavax Technologies Corporation, Berkeley, California, United States of America
⨯
Simon M. Barratt-Boyes

* E-mail: smbb@pitt.edu

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯

Blocking TLR7- and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection

Muhamuda Kader,
Amanda P. Smith,
Cristiana Guiducci,
Elizabeth R. Wonderlich,
Daniel Normolle,
Simon C. Watkins,
Franck J. Barrat,
Simon M. Barratt-Boyes

Published: July 25, 2013
https://doi.org/10.1371/journal.ppat.1003530

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