Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR)

Aravindan Ilangovan; Matthew Fletcher; Giordano Rampioni; Christian Pustelny; Kendra Rumbaugh; Stephan Heeb; Miguel Cámara; Alex Truman; Siri Ram Chhabra; Jonas Emsley; Paul Williams

doi:10.1371/journal.ppat.1003508

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Peer-reviewed

Research Article

Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR)

Aravindan Ilangovan,

Current address: Research Department of Structural & Molecular Biology, Birkbeck and University College, London, United Kingdom.

Affiliations Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Pharmacy, University of Nottingham, University Park, Nottingham, United Kingdom
⨯
Matthew Fletcher,

Affiliations Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
⨯
Giordano Rampioni,

Current address: Dept. of Biology, University of Roma Tre, Rome, Italy.

Affiliations Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
⨯
Christian Pustelny,

Current address: Helmholtz Center for Infection Research, Braunschweig, Germany.

Affiliations Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
⨯
Kendra Rumbaugh,

Affiliation Department of Surgery, University of Texas, Lubbock, Texas, United States of America
⨯
Stephan Heeb,

Affiliations Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
⨯
Miguel Cámara,

Affiliations Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
⨯
Alex Truman,

Affiliations Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
⨯
Siri Ram Chhabra,

Affiliations Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
⨯
Jonas Emsley,

Affiliations Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Pharmacy, University of Nottingham, University Park, Nottingham, United Kingdom
⨯
Paul Williams

* E-mail: paul.williams@nottingham.ac.uk

Affiliations Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
⨯

Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR)

Aravindan Ilangovan,
Matthew Fletcher,
Giordano Rampioni,
Christian Pustelny,
Kendra Rumbaugh,
Stephan Heeb,
Miguel Cámara,
Alex Truman,
Siri Ram Chhabra,
Jonas Emsley

Published: July 25, 2013
https://doi.org/10.1371/journal.ppat.1003508

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Crystal structure
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