Location of the CD8 T Cell Epitope within the Antigenic Precursor Determines Immunogenicity and Protection against the Toxoplasma gondii Parasite

Virginie Feliu; Virginie Vasseur; Harshita S. Grover; H. Hamlet Chu; Mark J. Brown; Jeremy Wang; Jon P. Boyle; Ellen A. Robey; Nilabh Shastri; Nicolas Blanchard

doi:10.1371/journal.ppat.1003449

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Peer-reviewed

Research Article

Location of the CD8 T Cell Epitope within the Antigenic Precursor Determines Immunogenicity and Protection against the Toxoplasma gondii Parasite

Virginie Feliu ,

¶First and senior authors contributed equally to this work.

Affiliations INSERM, U1043, Toulouse, France, CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France
⨯
Virginie Vasseur ,

¶First and senior authors contributed equally to this work.

Affiliations INSERM, U1043, Toulouse, France, CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France
⨯
Harshita S. Grover,

Affiliation Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America
⨯
H. Hamlet Chu,

Affiliation Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America
⨯
Mark J. Brown,

Affiliation Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Jeremy Wang,

Affiliation Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America
⨯
Jon P. Boyle,

Affiliation Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Ellen A. Robey,

Affiliation Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America
⨯
Nilabh Shastri ,

¶First and senior authors contributed equally to this work.

Affiliation Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America
⨯
Nicolas Blanchard

* E-mail: nicolas.blanchard@inserm.fr

¶First and senior authors contributed equally to this work.

Affiliations INSERM, U1043, Toulouse, France, CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France
⨯

Location of the CD8 T Cell Epitope within the Antigenic Precursor Determines Immunogenicity and Protection against the Toxoplasma gondii Parasite

Virginie Feliu,
Virginie Vasseur,
Harshita S. Grover,
H. Hamlet Chu,
Mark J. Brown,
Jeremy Wang,
Jon P. Boyle,
Ellen A. Robey,
Nilabh Shastri,
Nicolas Blanchard

Published: June 20, 2013
https://doi.org/10.1371/journal.ppat.1003449

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01 Jul 2013
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Previous description of c-terminal position as critical for immunogenicity against Toxoplasma proteins Posted by jegomezmarin on 30 Jun 2013 at 16:02 GMT

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