Glycan Masking of Plasmodium vivax Duffy Binding Protein for Probing Protein Binding Function and Vaccine Development

Sowmya Sampath; Chris Carrico; Joel Janes; Sairam Gurumoorthy; Claire Gibson; Martin Melcher; Chetan E. Chitnis; Ruobing Wang; William R. Schief; Joseph D. Smith

doi:10.1371/journal.ppat.1003420

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Open Access

Peer-reviewed

Research Article

Glycan Masking of Plasmodium vivax Duffy Binding Protein for Probing Protein Binding Function and Vaccine Development

Sowmya Sampath ,

Contributed equally to this work with: Sowmya Sampath, Chris Carrico

Affiliation Seattle Biomedical Research Institute, Seattle, Washington, United States of America
⨯
Chris Carrico ,

Contributed equally to this work with: Sowmya Sampath, Chris Carrico

Affiliations Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Joel Janes,

Affiliation Seattle Biomedical Research Institute, Seattle, Washington, United States of America
⨯
Sairam Gurumoorthy,

Affiliation Seattle Biomedical Research Institute, Seattle, Washington, United States of America
⨯
Claire Gibson,

Affiliation Seattle Biomedical Research Institute, Seattle, Washington, United States of America
⨯
Martin Melcher,

Affiliation Seattle Biomedical Research Institute, Seattle, Washington, United States of America
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Chetan E. Chitnis,

Affiliation International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
⨯
Ruobing Wang,

Affiliation Seattle Biomedical Research Institute, Seattle, Washington, United States of America
⨯
William R. Schief ,

* E-mail: schief@scripps.edu (WRS); joseph.smith@sbri.org (JDS)

Affiliations Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Joseph D. Smith

* E-mail: schief@scripps.edu (WRS); joseph.smith@sbri.org (JDS)

Affiliations Seattle Biomedical Research Institute, Seattle, Washington, United States of America, Department of Pathobiology, University of Washington, Seattle, Washington, United States of America
⨯

Glycan Masking of Plasmodium vivax Duffy Binding Protein for Probing Protein Binding Function and Vaccine Development

Sowmya Sampath,
Chris Carrico,
Joel Janes,
Sairam Gurumoorthy,
Claire Gibson,
Martin Melcher,
Chetan E. Chitnis,
Ruobing Wang,
William R. Schief,
Joseph D. Smith

Published: June 13, 2013
https://doi.org/10.1371/journal.ppat.1003420

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Antibodies
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Glycosylation
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Yeast
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Blood plasma
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Binding analysis
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