Genome-wide RNAi Screen Reveals a New Role of a WNT/CTNNB1 Signaling Pathway as Negative Regulator of Virus-induced Innate Immune Responses

Martin Baril; Salwa Es-Saad; Laurent Chatel-Chaix; Karin Fink; Tram Pham; Valérie-Ann Raymond; Karine Audette; Anne-Sophie Guenier; Jean Duchaine; Marc Servant; Marc Bilodeau; Éric Cohen; Nathalie Grandvaux; Daniel Lamarre

doi:10.1371/journal.ppat.1003416

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Open Access

Peer-reviewed

Research Article

Genome-wide RNAi Screen Reveals a New Role of a WNT/CTNNB1 Signaling Pathway as Negative Regulator of Virus-induced Innate Immune Responses

Martin Baril ,

Contributed equally to this work with: Martin Baril, Salwa Es-Saad

Affiliation Institut de Recherche en Immunologie et en Cancérologie (IRIC), Université de Montréal, Montréal, Québec, Canada
⨯
Salwa Es-Saad ,

Contributed equally to this work with: Martin Baril, Salwa Es-Saad

Affiliation Institut de Recherche en Immunologie et en Cancérologie (IRIC), Université de Montréal, Montréal, Québec, Canada
⨯
Laurent Chatel-Chaix,

Affiliation Institut de Recherche en Immunologie et en Cancérologie (IRIC), Université de Montréal, Montréal, Québec, Canada
⨯
Karin Fink,

Affiliation Centre de Recherche du CHUM (CRCHUM), Hôpital Saint-Luc, Montréal, Québec, Canada
⨯
Tram Pham,

Affiliation Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada
⨯
Valérie-Ann Raymond,

Affiliation Centre de Recherche du CHUM (CRCHUM), Hôpital Saint-Luc, Montréal, Québec, Canada
⨯
Karine Audette,

Affiliation Institut de Recherche en Immunologie et en Cancérologie (IRIC), Université de Montréal, Montréal, Québec, Canada
⨯
Anne-Sophie Guenier,

Affiliation Institut de Recherche en Immunologie et en Cancérologie (IRIC), Université de Montréal, Montréal, Québec, Canada
⨯
Jean Duchaine,

Affiliation Institut de Recherche en Immunologie et en Cancérologie (IRIC), Université de Montréal, Montréal, Québec, Canada
⨯
Marc Servant,

Affiliation Faculté de Pharmacie, Université de Montréal, Montréal, Québec, Canada
⨯
Marc Bilodeau,

Affiliations Centre de Recherche du CHUM (CRCHUM), Hôpital Saint-Luc, Montréal, Québec, Canada, Faculté de Médecine, Université de Montréal, Montréal, Québec, Canada
⨯
Éric Cohen,

Affiliation Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada
⨯
Nathalie Grandvaux,

Affiliations Centre de Recherche du CHUM (CRCHUM), Hôpital Saint-Luc, Montréal, Québec, Canada, Faculté de Médecine, Université de Montréal, Montréal, Québec, Canada
⨯
Daniel Lamarre

* E-mail: daniel.lamarre@umontreal.ca

Affiliations Institut de Recherche en Immunologie et en Cancérologie (IRIC), Université de Montréal, Montréal, Québec, Canada, Centre de Recherche du CHUM (CRCHUM), Hôpital Saint-Luc, Montréal, Québec, Canada, Faculté de Médecine, Université de Montréal, Montréal, Québec, Canada
⨯

Genome-wide RNAi Screen Reveals a New Role of a WNT/CTNNB1 Signaling Pathway as Negative Regulator of Virus-induced Innate Immune Responses

Martin Baril,
Salwa Es-Saad,
Laurent Chatel-Chaix,
Karin Fink,
Tram Pham,
Valérie-Ann Raymond,
Karine Audette,
Anne-Sophie Guenier,
Jean Duchaine,
Marc Servant

Published: June 13, 2013
https://doi.org/10.1371/journal.ppat.1003416

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