IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins

Arun K. Haldar; Hector A. Saka; Anthony S. Piro; Joe Dan Dunn; Stanley C. Henry; Gregory A. Taylor; Eva M. Frickel; Raphael H. Valdivia; Jörn Coers

doi:10.1371/journal.ppat.1003414

Loading metrics

Open Access

Peer-reviewed

Research Article

IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins

Arun K. Haldar,

Affiliation Departments of Molecular Genetics and Microbiology, and Immunology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Hector A. Saka,

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Anthony S. Piro,

Affiliation Departments of Molecular Genetics and Microbiology, and Immunology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Joe Dan Dunn,

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Stanley C. Henry,

Affiliations Departments of Medicine, Molecular Genetics and Microbiology, and Immunology and Center for the Study of Aging, Duke University, Durham, North Carolina, United States of America, Geriatric Research and Education and Clinical Center, Veteran Affairs Medical Center, Durham, North Carolina, United States of America
⨯
Gregory A. Taylor,

Affiliations Departments of Medicine, Molecular Genetics and Microbiology, and Immunology and Center for the Study of Aging, Duke University, Durham, North Carolina, United States of America, Geriatric Research and Education and Clinical Center, Veteran Affairs Medical Center, Durham, North Carolina, United States of America
⨯
Eva M. Frickel,

Affiliation Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom
⨯
Raphael H. Valdivia,

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Jörn Coers

* E-mail: jorn.coers@duke.edu

Affiliation Departments of Molecular Genetics and Microbiology, and Immunology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯

IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins

Arun K. Haldar,
Hector A. Saka,
Anthony S. Piro,
Joe Dan Dunn,
Stanley C. Henry,
Gregory A. Taylor,
Eva M. Frickel,
Raphael H. Valdivia,
Jörn Coers

Published: June 13, 2013
https://doi.org/10.1371/journal.ppat.1003414

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Chlamydia trachomatis
Is the Subject Area "Chlamydia trachomatis" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Toxoplasma gondii
Is the Subject Area "Toxoplasma gondii" applicable to this article?

Thanks for your feedback.
Vacuoles
Is the Subject Area "Vacuoles" applicable to this article?

Thanks for your feedback.
Lipids
Is the Subject Area "Lipids" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Autophagic cell death
Is the Subject Area "Autophagic cell death" applicable to this article?

Thanks for your feedback.
Guanosine triphosphatase
Is the Subject Area "Guanosine triphosphatase" applicable to this article?

Thanks for your feedback.