Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

• Jean-Philippe Julien,

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America

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• Devin Sok,

  Affiliations IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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• Reza Khayat,

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America

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• Jeong Hyun Lee,

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America

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• Katie J. Doores,

  Affiliations IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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• Laura M. Walker,

  Affiliations IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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• Alejandra Ramos,

  Affiliation IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America

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• Devan C. Diwanji,

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America

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• Robert Pejchal,

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America

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• Albert Cupo,

  Affiliation Weill Medical College of Cornell University, New York, New York, United States of America

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• Umesh Katpally,

  Affiliation Weill Medical College of Cornell University, New York, New York, United States of America

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• Rafael S. Depetris,

  Affiliation Weill Medical College of Cornell University, New York, New York, United States of America

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• Robyn L. Stanfield,

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America

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• Ryan McBride,

  Affiliation Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America

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• Andre J. Marozsan,

  Affiliation Weill Medical College of Cornell University, New York, New York, United States of America

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• James C. Paulson,

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America

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• Rogier W. Sanders,

  Affiliations Weill Medical College of Cornell University, New York, New York, United States of America, Department of Medical Microbiology, Academic Medical Center, Amsterdam, Netherlands

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• John P. Moore,

  Affiliation Weill Medical College of Cornell University, New York, New York, United States of America

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• Dennis R. Burton,

  Affiliations IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, United States of America

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• Pascal Poignard,

  Affiliations IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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• Andrew B. Ward ,

  * E-mail: abward@scripps.edu (ABW); wilson@scripps.edu (IAW)

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America

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•  [ ... ],
• Ian A. Wilson

  * E-mail: abward@scripps.edu (ABW); wilson@scripps.edu (IAW)

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America, Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

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