IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

Amina A. Negash; Hilario J. Ramos; Nanette Crochet; Daryl T. Y. Lau; Brian Doehle; Neven Papic; Don A. Delker; Juandy Jo; Antonio Bertoletti; Curt H. Hagedorn; Michael Gale Jr

doi:10.1371/journal.ppat.1003330

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Open Access

Peer-reviewed

Research Article

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

Amina A. Negash,

Affiliation Center for the Study of Hepatitis C Virus Infection and Immunity, Department of Immunology, University of Washington, Seattle, Washington, United States of America
⨯
Hilario J. Ramos,

Affiliation Center for the Study of Hepatitis C Virus Infection and Immunity, Department of Immunology, University of Washington, Seattle, Washington, United States of America
⨯
Nanette Crochet,

Affiliation Center for the Study of Hepatitis C Virus Infection and Immunity, Department of Immunology, University of Washington, Seattle, Washington, United States of America
⨯
Daryl T. Y. Lau,

Affiliation Liver Center, Division of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Brian Doehle,

Affiliation Center for the Study of Hepatitis C Virus Infection and Immunity, Department of Immunology, University of Washington, Seattle, Washington, United States of America
⨯
Neven Papic,

Affiliation Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Utah, Salt Lake City, Utah, United States of America
⨯
Don A. Delker,

Affiliation Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Utah, Salt Lake City, Utah, United States of America
⨯
Juandy Jo,

Affiliations Viral Hepatitis Laboratory, Singapore Institute for Clinical Sciences, Agency of Science Technology and Research (A*STAR), Singapore, Program Emerging Viral Diseases Unit, Duke-NUS Graduate Medical School, Singapore
⨯
Antonio Bertoletti,

Affiliations Viral Hepatitis Laboratory, Singapore Institute for Clinical Sciences, Agency of Science Technology and Research (A*STAR), Singapore, Program Emerging Viral Diseases Unit, Duke-NUS Graduate Medical School, Singapore
⨯
Curt H. Hagedorn,

Affiliation Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Utah, Salt Lake City, Utah, United States of America
⨯
Michael Gale Jr

* E-mail: mgale@uw.edu

Affiliation Center for the Study of Hepatitis C Virus Infection and Immunity, Department of Immunology, University of Washington, Seattle, Washington, United States of America
⨯

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

Amina A. Negash,
Hilario J. Ramos,
Nanette Crochet,
Daryl T. Y. Lau,
Brian Doehle,
Neven Papic,
Don A. Delker,
Juandy Jo,
Antonio Bertoletti,
Curt H. Hagedorn

Published: April 25, 2013
https://doi.org/10.1371/journal.ppat.1003330

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Hepatitis C virus
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Macrophages
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Liver diseases
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Immune receptor signaling
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Inflammasomes
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Chronic hepatitis
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Inflammatory diseases
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Viral gene expression
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