Regulatory T Cells Negatively Affect IL-2 Production of Effector T Cells through CD39/Adenosine Pathway in HIV Infection

Mohammad-Ali Jenabian; Nabila Seddiki; Ahmad Yatim; Matthieu Carriere; Anne Hulin; Mehwish Younas; Elnaz Ghadimi; Ayrin Kök; Jean-Pierre Routy; Alain Tremblay; Jean Sévigny; Jean-Daniel Lelievre; Yves Levy

doi:10.1371/journal.ppat.1003319

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Peer-reviewed

Research Article

Regulatory T Cells Negatively Affect IL-2 Production of Effector T Cells through CD39/Adenosine Pathway in HIV Infection

Mohammad-Ali Jenabian,

Affiliations INSERM U955, Equipe 16, Créteil, France, Faculté de Médecine, Université Paris Est Créteil, Créteil, France
⨯
Nabila Seddiki,

Affiliations INSERM U955, Equipe 16, Créteil, France, Faculté de Médecine, Université Paris Est Créteil, Créteil, France, Vaccine Research Institute, Agence Nationale de Recherche sur le Sida et les hépatites virales (ANRS) HIV Vaccine Network (AHVN), Créteil, France
⨯
Ahmad Yatim,

Affiliations INSERM U955, Equipe 16, Créteil, France, Faculté de Médecine, Université Paris Est Créteil, Créteil, France
⨯
Matthieu Carriere,

Affiliations INSERM U955, Equipe 16, Créteil, France, Faculté de Médecine, Université Paris Est Créteil, Créteil, France
⨯
Anne Hulin,

Affiliation Groupe Henri-Mondor Albert-Chènevière, Laboratory of Pharmacology and Toxicology, Créteil, France
⨯
Mehwish Younas,

Affiliations INSERM U955, Equipe 16, Créteil, France, Faculté de Médecine, Université Paris Est Créteil, Créteil, France
⨯
Elnaz Ghadimi,

Affiliation Faculty of Dentistry, McGill University, Montréal, Québec, Canada
⨯
Ayrin Kök,

Affiliations INSERM U955, Equipe 16, Créteil, France, Faculté de Médecine, Université Paris Est Créteil, Créteil, France
⨯
Jean-Pierre Routy,

Affiliation Division of Hematology and Chronic Viral Illness Service, McGill University Health Centre, Montreal, Québec, Canada
⨯
Alain Tremblay,

Affiliation Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHU de Québec, and Département de Microbiologie-Infectiologie et d'Immunologie, Faculté de Médecine, Université Laval, Québec, Québec, Canada
⨯
Jean Sévigny,

Affiliation Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHU de Québec, and Département de Microbiologie-Infectiologie et d'Immunologie, Faculté de Médecine, Université Laval, Québec, Québec, Canada
⨯
Jean-Daniel Lelievre,

Affiliations INSERM U955, Equipe 16, Créteil, France, Faculté de Médecine, Université Paris Est Créteil, Créteil, France, Vaccine Research Institute, Agence Nationale de Recherche sur le Sida et les hépatites virales (ANRS) HIV Vaccine Network (AHVN), Créteil, France, Groupe Henri-Mondor Albert-Chènevière, Immunologie Clinique, Créteil, France
⨯
Yves Levy

* E-mail: yves.levy@hmn.aphp.fr

Affiliations INSERM U955, Equipe 16, Créteil, France, Faculté de Médecine, Université Paris Est Créteil, Créteil, France, Vaccine Research Institute, Agence Nationale de Recherche sur le Sida et les hépatites virales (ANRS) HIV Vaccine Network (AHVN), Créteil, France, Groupe Henri-Mondor Albert-Chènevière, Immunologie Clinique, Créteil, France
⨯

Regulatory T Cells Negatively Affect IL-2 Production of Effector T Cells through CD39/Adenosine Pathway in HIV Infection

Mohammad-Ali Jenabian,
Nabila Seddiki,
Ahmad Yatim,
Matthieu Carriere,
Anne Hulin,
Mehwish Younas,
Elnaz Ghadimi,
Ayrin Kök,
Jean-Pierre Routy,
Alain Tremblay

Published: April 25, 2013
https://doi.org/10.1371/journal.ppat.1003319

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DNA methylation
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HIV infections
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