Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

Julien Pothlichet; Isabelle Meunier; Beckley K. Davis; Jenny P-Y. Ting; Emil Skamene; Veronika von Messling; Silvia M. Vidal

doi:10.1371/journal.ppat.1003256

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Open Access

Peer-reviewed

Research Article

Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

Julien Pothlichet ,

* E-mail: julien.pothlichet@pasteur.fr (JP); silvia.vidal@mcgill.ca (SMV)

Affiliations Department of Human Genetics, McGill University, Montreal, Quebec, Canada, McGill Centre for the Study of Host Resistance, McGill University, Montreal, Quebec, Canada, Institut Pasteur, Centre François Jacob, Paris, France
⨯
Isabelle Meunier,

Affiliation INRS-Institut Armand-Frappier, Laval, Quebec, Canada
⨯
Beckley K. Davis,

Current address: Department of Biology, Franklin and Marshall College, Lancaster, Pennsylvania, United States of America

Affiliations Department of Microbiology and Immunology School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Jenny P-Y. Ting,

Affiliations Department of Microbiology and Immunology School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Emil Skamene,

Affiliations Department of Human Genetics, McGill University, Montreal, Quebec, Canada, McGill Centre for the Study of Host Resistance, McGill University, Montreal, Quebec, Canada
⨯
Veronika von Messling,

Affiliation INRS-Institut Armand-Frappier, Laval, Quebec, Canada
⨯
Silvia M. Vidal

* E-mail: julien.pothlichet@pasteur.fr (JP); silvia.vidal@mcgill.ca (SMV)

Affiliations Department of Human Genetics, McGill University, Montreal, Quebec, Canada, McGill Centre for the Study of Host Resistance, McGill University, Montreal, Quebec, Canada
⨯

Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

Julien Pothlichet,
Isabelle Meunier,
Beckley K. Davis,
Jenny P-Y. Ting,
Emil Skamene,
Veronika von Messling,
Silvia M. Vidal

Published: April 11, 2013
https://doi.org/10.1371/journal.ppat.1003256

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Influenza A virus
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Epithelial cells
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Small interfering RNA
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