Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity

Brian J. Laidlaw; Vilma Decman; Mohammed-Alkhatim A. Ali; Michael C. Abt; Amaya I. Wolf; Laurel A. Monticelli; Krystyna Mozdzanowska; Jill M. Angelosanto; David Artis; Jan Erikson; E. John Wherry

doi:10.1371/journal.ppat.1003207

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Open Access

Peer-reviewed

Research Article

Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity

Brian J. Laidlaw,

Current address: Department of Immunobiology, Yale University, New Haven, Connecticut.

Affiliation Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Vilma Decman,

Current address: Regeneron Pharmaceuticals, Tarrytown, New York.

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Mohammed-Alkhatim A. Ali,

Affiliation Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Michael C. Abt,

Affiliation Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Amaya I. Wolf,

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Laurel A. Monticelli,

Affiliation Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Krystyna Mozdzanowska,

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Jill M. Angelosanto,

Affiliation Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
David Artis,

Affiliation Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Jan Erikson,

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
E. John Wherry

* E-mail: wherry@mail.med.upenn.edu

Affiliation Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity

Brian J. Laidlaw,
Vilma Decman,
Mohammed-Alkhatim A. Ali,
Michael C. Abt,
Amaya I. Wolf,
Laurel A. Monticelli,
Krystyna Mozdzanowska,
Jill M. Angelosanto,
David Artis,
Jan Erikson

Published: March 14, 2013
https://doi.org/10.1371/journal.ppat.1003207

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