Poxvirus Targeting of E3 Ligase β-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-κB Activation and Promote Immune Evasion and Virulence

Daniel S. Mansur; Carlos Maluquer de Motes; Leonie Unterholzner; Rebecca P. Sumner; Brian J. Ferguson; Hongwei Ren; Pavla Strnadova; Andrew G. Bowie; Geoffrey L. Smith

doi:10.1371/journal.ppat.1003183

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Peer-reviewed

Research Article

Poxvirus Targeting of E3 Ligase β-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-κB Activation and Promote Immune Evasion and Virulence

Daniel S. Mansur ,

Contributed equally to this work with: Daniel S. Mansur, Carlos Maluquer de Motes

Current address: Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Universidade Federal de Santa Catarina, Florianopolis, Brazil.

Affiliation Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom
⨯
Carlos Maluquer de Motes ,

Contributed equally to this work with: Daniel S. Mansur, Carlos Maluquer de Motes

Affiliations Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
⨯
Leonie Unterholzner,

Affiliation School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
⨯
Rebecca P. Sumner,

Affiliations Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
⨯
Brian J. Ferguson,

Affiliations Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
⨯
Hongwei Ren,

Affiliations Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
⨯
Pavla Strnadova,

Affiliations Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
⨯
Andrew G. Bowie,

Affiliation School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
⨯
Geoffrey L. Smith

* E-mail: gls37@cam.ac.uk

Affiliations Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
⨯

Poxvirus Targeting of E3 Ligase β-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-κB Activation and Promote Immune Evasion and Virulence

Daniel S. Mansur,
Carlos Maluquer de Motes,
Leonie Unterholzner,
Rebecca P. Sumner,
Brian J. Ferguson,
Hongwei Ren,
Pavla Strnadova,
Andrew G. Bowie,
Geoffrey L. Smith

Published: February 28, 2013
https://doi.org/10.1371/journal.ppat.1003183

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