Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response

Nicolas Dreux; Jérémy Denizot; Margarita Martinez-Medina; Alexander Mellmann; Maria Billig; Dagmara Kisiela; Sujay Chattopadhyay; Evgeni Sokurenko; Christel Neut; Corinne Gower-Rousseau; Jean-Frédéric Colombel; Richard Bonnet; Arlette Darfeuille-Michaud; Nicolas Barnich

doi:10.1371/journal.ppat.1003141

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Open Access

Peer-reviewed

Research Article

Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response

Nicolas Dreux,

Affiliation M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France
⨯
Jérémy Denizot,

Affiliation M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France
⨯
Margarita Martinez-Medina,

Affiliation M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France
⨯
Alexander Mellmann,

Affiliation Institute of Hygiene, University Hospital Münster, Münster, Germany
⨯
Maria Billig,

Affiliation University of Washington School of Medicine, Department of Microbiology, Seattle, Washington, United States of America
⨯
Dagmara Kisiela,

Affiliation University of Washington School of Medicine, Department of Microbiology, Seattle, Washington, United States of America
⨯
Sujay Chattopadhyay,

Affiliation University of Washington School of Medicine, Department of Microbiology, Seattle, Washington, United States of America
⨯
Evgeni Sokurenko,

Affiliation University of Washington School of Medicine, Department of Microbiology, Seattle, Washington, United States of America
⨯
Christel Neut,

Affiliation Inserm U995, Université Lille II, Hôpital Claude Huriez, Lille, France
⨯
Corinne Gower-Rousseau,

Affiliation Inserm U995, Université Lille II, Hôpital Claude Huriez, Lille, France
⨯
Jean-Frédéric Colombel,

Affiliation Inserm U995, Université Lille II, Hôpital Claude Huriez, Lille, France
⨯
Richard Bonnet,

Affiliations M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France, Service de Bactériologie, CHU, Clermont-Ferrand, France
⨯
Arlette Darfeuille-Michaud,

Affiliations M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France, Service de Bactériologie, CHU, Clermont-Ferrand, France, Institut Universitaire de Technologie, Génie Biologique, Aubière, France
⨯
Nicolas Barnich

* E-mail: nicolas.barnich@u-clermont1.fr

Affiliations M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France, Institut Universitaire de Technologie, Génie Biologique, Aubière, France
⨯

Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response

Nicolas Dreux,
Jérémy Denizot,
Margarita Martinez-Medina,
Alexander Mellmann,
Maria Billig,
Dagmara Kisiela,
Sujay Chattopadhyay,
Evgeni Sokurenko,
Christel Neut,
Corinne Gower-Rousseau

Published: January 24, 2013
https://doi.org/10.1371/journal.ppat.1003141

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