4′-Phosphopantetheinyl Transferase PptT, a New Drug Target Required for Mycobacterium tuberculosis Growth and Persistence In Vivo

Cécile Leblanc; Thomas Prudhomme; Guillaume Tabouret; Aurélie Ray; Sophie Burbaud; Stéphanie Cabantous; Lionel Mourey; Christophe Guilhot; Christian Chalut

doi:10.1371/journal.ppat.1003097

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Open Access

Peer-reviewed

Research Article

4′-Phosphopantetheinyl Transferase PptT, a New Drug Target Required for Mycobacterium tuberculosis Growth and Persistence In Vivo

Cécile Leblanc,

Affiliations CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France
⨯
Thomas Prudhomme,

Current address: Biosentec, Toulouse, France.

Affiliations CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France
⨯
Guillaume Tabouret,

Current address: INRA UMR 1225, IHAP, Ecole Nationale Vétérinaire, Toulouse, France.

Affiliations CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France
⨯
Aurélie Ray,

Current address: Trudeau Institute, Saranac Lake, New York, United States of America.

Affiliations CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France
⨯
Sophie Burbaud,

Affiliations CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France
⨯
Stéphanie Cabantous,

Affiliation Centre de Recherche en Cancérologie (CRCT), UMR 1037 INSERM-CNRS-UPS Institut Claudius Regaud, Toulouse, France
⨯
Lionel Mourey,

Affiliations CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France
⨯
Christophe Guilhot ,

* E-mail: Christian.Chalut@ipbs.fr (CC); Christophe.Guilhot@ipbs.fr (CG)

Affiliations CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France
⨯
Christian Chalut

* E-mail: Christian.Chalut@ipbs.fr (CC); Christophe.Guilhot@ipbs.fr (CG)

Affiliations CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France
⨯

4′-Phosphopantetheinyl Transferase PptT, a New Drug Target Required for Mycobacterium tuberculosis Growth and Persistence In Vivo

Cécile Leblanc,
Thomas Prudhomme,
Guillaume Tabouret,
Aurélie Ray,
Sophie Burbaud,
Stéphanie Cabantous,
Lionel Mourey,
Christophe Guilhot,
Christian Chalut

Published: December 20, 2012
https://doi.org/10.1371/journal.ppat.1003097

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