MiniCD4 Microbicide Prevents HIV Infection of Human Mucosal Explants and Vaginal Transmission of SHIV162P3 in Cynomolgus Macaques

Nathalie Dereuddre-Bosquet; Laurence Morellato-Castillo; Joachim Brouwers; Patrick Augustijns; Kawthar Bouchemal; Gilles Ponchel; Oscar H. P. Ramos; Carolina Herrera; Martha Stefanidou; Robin Shattock; Leo Heyndrickx; Guido Vanham; Pascal Kessler; Roger Le Grand; Loïc Martin

doi:10.1371/journal.ppat.1003071

Loading metrics

Open Access

Peer-reviewed

Research Article

MiniCD4 Microbicide Prevents HIV Infection of Human Mucosal Explants and Vaginal Transmission of SHIV_162P3 in Cynomolgus Macaques

Nathalie Dereuddre-Bosquet,

Affiliations CEA, Division of Immuno-Virology, iMETI, Fontenay-aux Roses, France, Paris-Sud University, UMRE01, Orsay, France
⨯
Laurence Morellato-Castillo,

Affiliation CEA, iBiTecS, Service d'Ingénierie Moléculaire des Protéines, Gif sur Yvette, France
⨯
Joachim Brouwers,

Affiliation Katholieke Universiteit Leuven, Leuven, Belgium
⨯
Patrick Augustijns,

Affiliation Katholieke Universiteit Leuven, Leuven, Belgium
⨯
Kawthar Bouchemal,

Affiliation Paris-Sud University, Faculty of Pharmacy, Chatenay-Malabry, France
⨯
Gilles Ponchel,

Affiliation Paris-Sud University, Faculty of Pharmacy, Chatenay-Malabry, France
⨯
Oscar H. P. Ramos,

Affiliation CEA, iBiTecS, Service d'Ingénierie Moléculaire des Protéines, Gif sur Yvette, France
⨯
Carolina Herrera,

Affiliation Section of Infectious Diseases, Faculty of Medicine, St Mary's Campus, Imperial College, London, United Kingdom
⨯
Martha Stefanidou,

Affiliation Department of Pediatrics and Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Robin Shattock,

Affiliation Section of Infectious Diseases, Faculty of Medicine, St Mary's Campus, Imperial College, London, United Kingdom
⨯
Leo Heyndrickx,

Affiliation Institute of Tropical Medicine and University of Antwerp, Antwerp, Belgium
⨯
Guido Vanham,

Affiliation Institute of Tropical Medicine and University of Antwerp, Antwerp, Belgium
⨯
Pascal Kessler,

Affiliation CEA, iBiTecS, Service d'Ingénierie Moléculaire des Protéines, Gif sur Yvette, France
⨯
Roger Le Grand,

Affiliations CEA, Division of Immuno-Virology, iMETI, Fontenay-aux Roses, France, Paris-Sud University, UMRE01, Orsay, France
⨯
Loïc Martin

* E-mail: loic.martin@cea.fr

Affiliation CEA, iBiTecS, Service d'Ingénierie Moléculaire des Protéines, Gif sur Yvette, France
⨯

MiniCD4 Microbicide Prevents HIV Infection of Human Mucosal Explants and Vaginal Transmission of SHIV_162P3 in Cynomolgus Macaques

Nathalie Dereuddre-Bosquet,
Laurence Morellato-Castillo,
Joachim Brouwers,
Patrick Augustijns,
Kawthar Bouchemal,
Gilles Ponchel,
Oscar H. P. Ramos,
Carolina Herrera,
Martha Stefanidou,
Robin Shattock

Published: December 6, 2012
https://doi.org/10.1371/journal.ppat.1003071

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Macaque
Is the Subject Area "Macaque" applicable to this article?

Thanks for your feedback.
Microbicides
Is the Subject Area "Microbicides" applicable to this article?

Thanks for your feedback.
Blood plasma
Is the Subject Area "Blood plasma" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
HIV-1
Is the Subject Area "HIV-1" applicable to this article?

Thanks for your feedback.
Pharmacokinetics
Is the Subject Area "Pharmacokinetics" applicable to this article?

Thanks for your feedback.
HIV
Is the Subject Area "HIV" applicable to this article?

Thanks for your feedback.
Viremia
Is the Subject Area "Viremia" applicable to this article?

Thanks for your feedback.