Influenza Human Monoclonal Antibody 1F1 Interacts with Three Major Antigenic Sites and Residues Mediating Human Receptor Specificity in H1N1 Viruses

Tshidi Tsibane; Damian C. Ekiert; Jens C. Krause; Osvaldo Martinez; James E. Crowe Jr.; Ian A. Wilson; Christopher F. Basler

doi:10.1371/journal.ppat.1003067

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Research Article

Influenza Human Monoclonal Antibody 1F1 Interacts with Three Major Antigenic Sites and Residues Mediating Human Receptor Specificity in H1N1 Viruses

Tshidi Tsibane ,

Contributed equally to this work with: Tshidi Tsibane, Damian C. Ekiert, Jens C. Krause

Affiliation Department of Microbiology, Mount Sinai School of Medicine, New York City, New York, United States of America
⨯
Damian C. Ekiert ,

Contributed equally to this work with: Tshidi Tsibane, Damian C. Ekiert, Jens C. Krause

Affiliation Department of Molecular Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Jens C. Krause ,

Contributed equally to this work with: Tshidi Tsibane, Damian C. Ekiert, Jens C. Krause

Affiliation Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Osvaldo Martinez,

Affiliation Department of Microbiology, Mount Sinai School of Medicine, New York City, New York, United States of America
⨯
James E. Crowe Jr. ,

* E-mail: james.crowe@vanderbilt.edu (JEC); wilson@scripps.edu (IAW); chris.basler@mssm.edu (CFB)

Affiliations Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Ian A. Wilson ,

* E-mail: james.crowe@vanderbilt.edu (JEC); wilson@scripps.edu (IAW); chris.basler@mssm.edu (CFB)

Affiliation Department of Molecular Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Christopher F. Basler

* E-mail: james.crowe@vanderbilt.edu (JEC); wilson@scripps.edu (IAW); chris.basler@mssm.edu (CFB)

Affiliation Department of Microbiology, Mount Sinai School of Medicine, New York City, New York, United States of America
⨯

Influenza Human Monoclonal Antibody 1F1 Interacts with Three Major Antigenic Sites and Residues Mediating Human Receptor Specificity in H1N1 Viruses

Tshidi Tsibane,
Damian C. Ekiert,
Jens C. Krause,
Osvaldo Martinez,
James E. Crowe Jr.,
Ian A. Wilson,
Christopher F. Basler

Published: December 6, 2012
https://doi.org/10.1371/journal.ppat.1003067

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