Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

Ricardo Rajsbaum; Randy A. Albrecht; May K. Wang; Natalya P. Maharaj; Gijs A. Versteeg; Estanislao Nistal-Villán; Adolfo García-Sastre; Michaela U. Gack

doi:10.1371/journal.ppat.1003059

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Peer-reviewed

Research Article

Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

Ricardo Rajsbaum,

Affiliations Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Randy A. Albrecht,

Affiliations Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
May K. Wang,

Affiliation Department of Microbiology and Immunobiology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America
⨯
Natalya P. Maharaj,

Affiliation Department of Microbiology and Immunobiology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America
⨯
Gijs A. Versteeg,

Affiliations Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Estanislao Nistal-Villán,

Current address: Center for Applied Medical Research (CIMA), Universidad de Navarra, Pamplona, Spain.

Affiliation Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Adolfo García-Sastre ,

* E-mail: adolfo.garcia-sastre@mssm.edu (AGS); michaela_gack@hms.harvard.edu (MUG)

Affiliations Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Michaela U. Gack

* E-mail: adolfo.garcia-sastre@mssm.edu (AGS); michaela_gack@hms.harvard.edu (MUG)

Affiliation Department of Microbiology and Immunobiology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America
⨯

Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

Ricardo Rajsbaum,
Randy A. Albrecht,
May K. Wang,
Natalya P. Maharaj,
Gijs A. Versteeg,
Estanislao Nistal-Villán,
Adolfo García-Sastre,
Michaela U. Gack

Published: November 29, 2012
https://doi.org/10.1371/journal.ppat.1003059

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Ubiquitination
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