Early Mechanisms of Pathobiology Are Revealed by Transcriptional Temporal Dynamics in Hippocampal CA1 Neurons of Prion Infected Mice

Anna Majer; Sarah J. Medina; Yulian Niu; Bernard Abrenica; Kathy J. Manguiat; Kathy L. Frost; Clark S. Philipson; Debra L. Sorensen; Stephanie A. Booth

doi:10.1371/journal.ppat.1003002

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Open Access

Peer-reviewed

Research Article

Early Mechanisms of Pathobiology Are Revealed by Transcriptional Temporal Dynamics in Hippocampal CA1 Neurons of Prion Infected Mice

Anna Majer,

Affiliations Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada
⨯
Sarah J. Medina,

Affiliation Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
⨯
Yulian Niu,

Affiliation Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
⨯
Bernard Abrenica,

Affiliation Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
⨯
Kathy J. Manguiat,

Affiliation Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
⨯
Kathy L. Frost,

Affiliation Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
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Clark S. Philipson,

Affiliation Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
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Debra L. Sorensen,

Affiliation Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
⨯
Stephanie A. Booth

* E-mail: Stephanie.Booth@phac-aspc.gc.ca

Affiliations Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada
⨯

Early Mechanisms of Pathobiology Are Revealed by Transcriptional Temporal Dynamics in Hippocampal CA1 Neurons of Prion Infected Mice

Anna Majer,
Sarah J. Medina,
Yulian Niu,
Bernard Abrenica,
Kathy J. Manguiat,
Kathy L. Frost,
Clark S. Philipson,
Debra L. Sorensen,
Stephanie A. Booth

Published: November 8, 2012
https://doi.org/10.1371/journal.ppat.1003002

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MicroRNAs
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Neurons
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Prion diseases
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Hippocampus
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Neuronal dendrites
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Gene expression
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Animal prion diseases
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Neuronal death
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