Distinct Effects on Diversifying Selection by Two Mechanisms of Immunity against Streptococcus pneumoniae

Yuan Li; Todd Gierahn; Claudette M. Thompson; Krzysztof Trzciński; Christopher B. Ford; Nicholas Croucher; Paulo Gouveia; Jessica B. Flechtner; Richard Malley; Marc Lipsitch

doi:10.1371/journal.ppat.1002989

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Open Access

Peer-reviewed

Research Article

Distinct Effects on Diversifying Selection by Two Mechanisms of Immunity against Streptococcus pneumoniae

Yuan Li ,

Contributed equally to this work with: Yuan Li, Todd Gierahn

* E-mail: liyuan@hsph.harvard.edu

Affiliation Department of Epidemiology and Department of Immunology & Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Todd Gierahn ,

Contributed equally to this work with: Yuan Li, Todd Gierahn

Affiliation Genocea Biosciences, Inc., Cambridge, Massachusetts, United States of America
⨯
Claudette M. Thompson,

Affiliation Department of Epidemiology and Department of Immunology & Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Krzysztof Trzciński,

Affiliation Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Christopher B. Ford,

Affiliation Department of Epidemiology and Department of Immunology & Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Nicholas Croucher,

Affiliation Department of Epidemiology and Department of Immunology & Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Paulo Gouveia,

Affiliation Genocea Biosciences, Inc., Cambridge, Massachusetts, United States of America
⨯
Jessica B. Flechtner,

Affiliation Genocea Biosciences, Inc., Cambridge, Massachusetts, United States of America
⨯
Richard Malley,

Affiliation Division of Infectious Diseases, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Marc Lipsitch

Affiliation Department of Epidemiology and Department of Immunology & Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯

Distinct Effects on Diversifying Selection by Two Mechanisms of Immunity against Streptococcus pneumoniae

Yuan Li,
Todd Gierahn,
Claudette M. Thompson,
Krzysztof Trzciński,
Christopher B. Ford,
Nicholas Croucher,
Paulo Gouveia,
Jessica B. Flechtner,
Richard Malley,
Marc Lipsitch

Published: November 8, 2012
https://doi.org/10.1371/journal.ppat.1002989

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Cell-mediated immunity
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DNA-binding proteins
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Pneumococcus
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Antigenic variation
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