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Open Access
Peer-reviewed
Research Article
Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules
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Steven Johnson ,
Contributed equally to this work with: Steven Johnson, Lionel Tan, Stijn van der Veen, Joseph Caesar, Elena Goicoechea De Jorge, Rachel J. Harding
Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
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Lionel Tan ,
Contributed equally to this work with: Steven Johnson, Lionel Tan, Stijn van der Veen, Joseph Caesar, Elena Goicoechea De Jorge, Rachel J. Harding
Affiliation Centre for Molecular Microbiology and Infection, Imperial College, London, United Kingdom
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Stijn van der Veen ,
Contributed equally to this work with: Steven Johnson, Lionel Tan, Stijn van der Veen, Joseph Caesar, Elena Goicoechea De Jorge, Rachel J. Harding
Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
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Joseph Caesar ,
Contributed equally to this work with: Steven Johnson, Lionel Tan, Stijn van der Veen, Joseph Caesar, Elena Goicoechea De Jorge, Rachel J. Harding
Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
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Elena Goicoechea De Jorge ,
Contributed equally to this work with: Steven Johnson, Lionel Tan, Stijn van der Veen, Joseph Caesar, Elena Goicoechea De Jorge, Rachel J. Harding
Affiliation Centre for Complement and Inflammation Research (CCIR), Department of Medicine, Imperial College, London, United Kingdom
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Rachel J. Harding ,
Contributed equally to this work with: Steven Johnson, Lionel Tan, Stijn van der Veen, Joseph Caesar, Elena Goicoechea De Jorge, Rachel J. Harding
Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
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Xilian Bai,
Affiliation Vaccine Evaluation Unit, Public Health Laboratory, Manchester Medical Microbiology Partnership, Manchester, United Kingdom
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Rachel M. Exley,
Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
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Philip N. Ward,
Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
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Nicola Ruivo,
Affiliation Centre for Molecular Microbiology and Infection, Imperial College, London, United Kingdom
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Kaushali Trivedi,
Affiliation Centre for Molecular Microbiology and Infection, Imperial College, London, United Kingdom
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Elspeth Cumber,
Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
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Rhian Jones,
Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
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Luke Newham,
Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
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David Staunton,
Affiliation Department of Biochemistry, University of Oxford, Oxford, United Kingdom
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Rafael Ufret-Vincenty,
Affiliation Department of Ophthalmology, UT Southwestern Medical Center, Dallas, Texas, United States of America
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Ray Borrow,
Affiliation Vaccine Evaluation Unit, Public Health Laboratory, Manchester Medical Microbiology Partnership, Manchester, United Kingdom
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Matthew C. Pickering ,
* E-mail: m.pickering@imperial.ac.uk (MCP); susan.lea@path.ox.ac.uk (SML); christoph.tang@path.ox.ac.uk (CMT)
Affiliation Centre for Complement and Inflammation Research (CCIR), Department of Medicine, Imperial College, London, United Kingdom
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Susan M. Lea ,
* E-mail: m.pickering@imperial.ac.uk (MCP); susan.lea@path.ox.ac.uk (SML); christoph.tang@path.ox.ac.uk (CMT)
Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
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Christoph M. Tang
* E-mail: m.pickering@imperial.ac.uk (MCP); susan.lea@path.ox.ac.uk (SML); christoph.tang@path.ox.ac.uk (CMT)
Affiliations Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom, Centre for Molecular Microbiology and Infection, Imperial College, London, United Kingdom
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Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules
- Steven Johnson,
- Lionel Tan,
- Stijn van der Veen,
- Joseph Caesar,
- Elena Goicoechea De Jorge,
- Rachel J. Harding,
- Xilian Bai,
- Rachel M. Exley,
- Philip N. Ward,
- Nicola Ruivo
- Published: October 25, 2012
- https://doi.org/10.1371/journal.ppat.1002981