Unbiased Mutagenesis of MHV68 LANA Reveals a DNA-Binding Domain Required for LANA Function In Vitro and In Vivo

Open Access

Peer-reviewed

Research Article

Clinton R. Paden,

Affiliations Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America, Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, Georgia, United States of America
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J. Craig Forrest,

Affiliation Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
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Scott A. Tibbetts,

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America
⨯
Samuel H. Speck

* E-mail: sspeck@emory.edu

Affiliation Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America
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Luciferase
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DNA-binding proteins
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Polymerase chain reaction
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Viral replication
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DNA transcription
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Transcriptional control
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Viral persistence and latency
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293T cells
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