Deep Sequencing of Antiviral T-Cell Responses to HCMV and EBV in Humans Reveals a Stable Repertoire That Is Maintained for Many Years

P. L. Klarenbeek; E. B. M. Remmerswaal; I. J. M. ten Berge; M. E. Doorenspleet; B. D. C. van Schaik; R. E. E. Esveldt; S. D. Koch; A. ten Brinke; A. H. C. van Kampen; F. J. Bemelman; P. P. Tak; F. Baas; N. de Vries; R. A. W. van Lier

doi:10.1371/journal.ppat.1002889

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Peer-reviewed

Research Article

Deep Sequencing of Antiviral T-Cell Responses to HCMV and EBV in Humans Reveals a Stable Repertoire That Is Maintained for Many Years

P. L. Klarenbeek ,

Contributed equally to this work with: P. L. Klarenbeek, E. B. M. Remmerswaal

Affiliations Department of Clinical Immunology & Rheumatology, Academic Medical Center, Amsterdam, the Netherlands, Department of Genome Analysis, Academic Medical Center, Amsterdam, the Netherlands, Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands
⨯
E. B. M. Remmerswaal ,

Contributed equally to this work with: P. L. Klarenbeek, E. B. M. Remmerswaal

Affiliations Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands, Renal Transplant Unit, Academic Medical Center, Amsterdam, the Netherlands
⨯
I. J. M. ten Berge,

Affiliations Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands, Renal Transplant Unit, Academic Medical Center, Amsterdam, the Netherlands
⨯
M. E. Doorenspleet,

Affiliations Department of Clinical Immunology & Rheumatology, Academic Medical Center, Amsterdam, the Netherlands, Department of Genome Analysis, Academic Medical Center, Amsterdam, the Netherlands, Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands
⨯
B. D. C. van Schaik,

Affiliation Bioinformatics Laboratory, Academic Medical Center, Amsterdam, the Netherlands
⨯
R. E. E. Esveldt,

Affiliations Department of Clinical Immunology & Rheumatology, Academic Medical Center, Amsterdam, the Netherlands, Department of Genome Analysis, Academic Medical Center, Amsterdam, the Netherlands, Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands
⨯
S. D. Koch,

Affiliation Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands
⨯
A. ten Brinke,

Affiliation Sanquin Research at CLB and Landsteiner Laboratory, Amsterdam, the Netherlands
⨯
A. H. C. van Kampen,

Affiliation Bioinformatics Laboratory, Academic Medical Center, Amsterdam, the Netherlands
⨯
F. J. Bemelman,

Affiliation Renal Transplant Unit, Academic Medical Center, Amsterdam, the Netherlands
⨯
P. P. Tak,

Affiliation Department of Clinical Immunology & Rheumatology, Academic Medical Center, Amsterdam, the Netherlands
⨯
F. Baas,

Affiliation Department of Genome Analysis, Academic Medical Center, Amsterdam, the Netherlands
⨯
N. de Vries,

Affiliation Department of Clinical Immunology & Rheumatology, Academic Medical Center, Amsterdam, the Netherlands
⨯
R. A. W. van Lier

* E-mail: r.vanlier@sanquin.nl

Affiliations Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands, Sanquin Research at CLB and Landsteiner Laboratory, Amsterdam, the Netherlands
⨯

Deep Sequencing of Antiviral T-Cell Responses to HCMV and EBV in Humans Reveals a Stable Repertoire That Is Maintained for Many Years

P. L. Klarenbeek,
E. B. M. Remmerswaal,
I. J. M. ten Berge,
M. E. Doorenspleet,
B. D. C. van Schaik,
R. E. E. Esveldt,
S. D. Koch,
A. ten Brinke,
A. H. C. van Kampen,
F. J. Bemelman

Published: September 27, 2012
https://doi.org/10.1371/journal.ppat.1002889

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