Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

Rebecca M. DuBois; P. Jake Slavish; Brandi M. Baughman; Mi-Kyung Yun; Ju Bao; Richard J. Webby; Thomas R. Webb; Stephen W. White

doi:10.1371/journal.ppat.1002830

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Peer-reviewed

Research Article

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

Rebecca M. DuBois,

Affiliations Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
⨯
P. Jake Slavish,

Affiliation Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
⨯
Brandi M. Baughman,

Affiliations Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
⨯
Mi-Kyung Yun,

Affiliation Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
⨯
Ju Bao,

Affiliation Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
⨯
Richard J. Webby,

Affiliation Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
⨯
Thomas R. Webb,

Affiliations Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
⨯
Stephen W. White

* E-mail: Stephen.White@stjude.org

Affiliations Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
⨯

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

Rebecca M. DuBois,
P. Jake Slavish,
Brandi M. Baughman,
Mi-Kyung Yun,
Ju Bao,
Richard J. Webby,
Thomas R. Webb,
Stephen W. White

Published: August 2, 2012
https://doi.org/10.1371/journal.ppat.1002830

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