Polyfunctional Type-1, -2, and -17 CD8+ T Cell Responses to Apoptotic Self-Antigens Correlate with the Chronic Evolution of Hepatitis C Virus Infection

Debora Franceschini; Paola Del Porto; Silvia Piconese; Emanuele Trella; Daniele Accapezzato; Marino Paroli; Stefania Morrone; Enza Piccolella; Enea Spada; Alfonso Mele; John Sidney; Alessandro Sette; Vincenzo Barnaba

doi:10.1371/journal.ppat.1002759

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Peer-reviewed

Research Article

Polyfunctional Type-1, -2, and -17 CD8⁺ T Cell Responses to Apoptotic Self-Antigens Correlate with the Chronic Evolution of Hepatitis C Virus Infection

Debora Franceschini,

Affiliation Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy
⨯
Paola Del Porto,

Affiliation Dipartimento di Biologia e Biotecnologie “Charles Darwin”, Sapienza Università di Roma, Rome, Italy
⨯
Silvia Piconese,

Affiliation Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy
⨯
Emanuele Trella,

Current address: Institute for Surgical Research and Hospital Management (ICFS) Oncology Group, University Hospital Basel, Basel, Switzerland.

Affiliation Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy
⨯
Daniele Accapezzato,

Affiliation Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy
⨯
Marino Paroli,

Affiliation Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche, Sapienza Università di Roma, Rome, Italy
⨯
Stefania Morrone,

Affiliation Dipartimento di Medicina Sperimentale, Sapienza Università di Roma, Rome, Italy
⨯
Enza Piccolella,

Affiliation Dipartimento di Biologia e Biotecnologie “Charles Darwin”, Sapienza Università di Roma, Rome, Italy
⨯
Enea Spada,

Affiliation National Centre of Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità, Rome, Italy
⨯
Alfonso Mele,

Affiliation National Centre of Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità, Rome, Italy
⨯
John Sidney,

Affiliation La Jolla Institute for Allergy and Immunology, San Diego, California, United States of America
⨯
Alessandro Sette,

Affiliation La Jolla Institute for Allergy and Immunology, San Diego, California, United States of America
⨯
Vincenzo Barnaba

* E-mail: vincenzo.barnaba@uniroma1.it

Affiliations Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy, Istituto Pasteur - Fondazione Cenci Bolognetti, Rome, Italy, Fondazione Andrea Cesalpino, Rome, Italy
⨯

Polyfunctional Type-1, -2, and -17 CD8⁺ T Cell Responses to Apoptotic Self-Antigens Correlate with the Chronic Evolution of Hepatitis C Virus Infection

Debora Franceschini,
Paola Del Porto,
Silvia Piconese,
Emanuele Trella,
Daniele Accapezzato,
Marino Paroli,
Stefania Morrone,
Enza Piccolella,
Enea Spada,
Alfonso Mele

Published: June 21, 2012
https://doi.org/10.1371/journal.ppat.1002759

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Apoptosis
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Hepatitis C virus
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