Structural Basis of Cytotoxicity Mediated by the Type III Secretion Toxin ExoU from Pseudomonas aeruginosa

Claire Gendrin; Carlos Contreras-Martel; Stéphanie Bouillot; Sylvie Elsen; David Lemaire; Dimitrios A. Skoufias; Philippe Huber; Ina Attree; Andréa Dessen

doi:10.1371/journal.ppat.1002637

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Peer-reviewed

Research Article

Structural Basis of Cytotoxicity Mediated by the Type III Secretion Toxin ExoU from Pseudomonas aeruginosa

Claire Gendrin,

Affiliations Bacterial Pathogenesis Group, Institut de Biologie Structurale (IBS), Université Grenoble I, Grenoble, France, Commissariat à l'Enérgie Atomique (CEA), Grenoble and Cadarache, France, Centre National de la Recherche Scientifique (CNRS), Grenoble and Cadarache, France
⨯
Carlos Contreras-Martel,

Affiliations Bacterial Pathogenesis Group, Institut de Biologie Structurale (IBS), Université Grenoble I, Grenoble, France, Commissariat à l'Enérgie Atomique (CEA), Grenoble and Cadarache, France, Centre National de la Recherche Scientifique (CNRS), Grenoble and Cadarache, France
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Stéphanie Bouillot,

Affiliations Commissariat à l'Enérgie Atomique (CEA), Grenoble and Cadarache, France, Centre National de la Recherche Scientifique (CNRS), Grenoble and Cadarache, France, Bacterial Pathogenesis and Cellular Responses, iRTSV, Université Grenoble I, Grenoble, France, INSERM UMR-S 1036, Biology of Cancer and Infection, Grenoble, France
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Sylvie Elsen,

Affiliations Commissariat à l'Enérgie Atomique (CEA), Grenoble and Cadarache, France, Centre National de la Recherche Scientifique (CNRS), Grenoble and Cadarache, France, Bacterial Pathogenesis and Cellular Responses, iRTSV, Université Grenoble I, Grenoble, France, INSERM UMR-S 1036, Biology of Cancer and Infection, Grenoble, France
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David Lemaire,

Affiliations Commissariat à l'Enérgie Atomique (CEA), Grenoble and Cadarache, France, Centre National de la Recherche Scientifique (CNRS), Grenoble and Cadarache, France, Laboratoire des Interactions Protéine Métal, IBEB, Université Aix-Marseille II, Saint Paul Lez Durance, France
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Dimitrios A. Skoufias,

Affiliations Commissariat à l'Enérgie Atomique (CEA), Grenoble and Cadarache, France, Centre National de la Recherche Scientifique (CNRS), Grenoble and Cadarache, France, Viral Infection and Cancer Group, IBS, Grenoble, France
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Philippe Huber,

Affiliations Commissariat à l'Enérgie Atomique (CEA), Grenoble and Cadarache, France, Centre National de la Recherche Scientifique (CNRS), Grenoble and Cadarache, France, Bacterial Pathogenesis and Cellular Responses, iRTSV, Université Grenoble I, Grenoble, France, INSERM UMR-S 1036, Biology of Cancer and Infection, Grenoble, France
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Ina Attree,

Affiliations Commissariat à l'Enérgie Atomique (CEA), Grenoble and Cadarache, France, Centre National de la Recherche Scientifique (CNRS), Grenoble and Cadarache, France, Bacterial Pathogenesis and Cellular Responses, iRTSV, Université Grenoble I, Grenoble, France, INSERM UMR-S 1036, Biology of Cancer and Infection, Grenoble, France
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Andréa Dessen

* E-mail: andrea.dessen@ibs.fr

Affiliations Bacterial Pathogenesis Group, Institut de Biologie Structurale (IBS), Université Grenoble I, Grenoble, France, Commissariat à l'Enérgie Atomique (CEA), Grenoble and Cadarache, France, Centre National de la Recherche Scientifique (CNRS), Grenoble and Cadarache, France
⨯

Structural Basis of Cytotoxicity Mediated by the Type III Secretion Toxin ExoU from Pseudomonas aeruginosa

Claire Gendrin,
Carlos Contreras-Martel,
Stéphanie Bouillot,
Sylvie Elsen,
David Lemaire,
Dimitrios A. Skoufias,
Philippe Huber,
Ina Attree,
Andréa Dessen

Published: April 5, 2012
https://doi.org/10.1371/journal.ppat.1002637

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Phospholipases
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Pseudomonas aeruginosa
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Toxins
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Membrane potential
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Cell membranes
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