Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections

• Clarissa Pozzi ,

  Contributed equally to this work with: Clarissa Pozzi, Elaine M. Waters

  Affiliations UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Elaine M. Waters ,

  Contributed equally to this work with: Clarissa Pozzi, Elaine M. Waters

  Affiliations UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

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• Justine K. Rudkin,

  Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

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• Carolyn R. Schaeffer,

  Affiliations Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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• Amanda J. Lohan,

  Affiliations UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

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• Pin Tong,

  Affiliations UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

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• Brendan J. Loftus,

  Affiliations UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

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• Gerald B. Pier,

  Affiliation Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Paul D. Fey,

  Affiliations Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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• Ruth C. Massey,

  Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

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• James P. O'Gara

  * E-mail: jim.ogara@ucd.ie

  Affiliations UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

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