Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity

Annalisa Bianco; Veronica Reghellin; Lorena Donnici; Simone Fenu; Reinaldo Alvarez; Chiara Baruffa; Francesco Peri; Massimiliano Pagani; Sergio Abrignani; Petra Neddermann; Raffaele De Francesco

doi:10.1371/journal.ppat.1002576

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Peer-reviewed

Research Article

Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity

Annalisa Bianco,

Affiliation Department of Genomics and Molecular Biology, Virology Program, Istituto Nazionale Genetica Molecolare (INGM), Milano, Italy
⨯
Veronica Reghellin,

Affiliation Department of Genomics and Molecular Biology, Virology Program, Istituto Nazionale Genetica Molecolare (INGM), Milano, Italy
⨯
Lorena Donnici,

Affiliation Department of Genomics and Molecular Biology, Virology Program, Istituto Nazionale Genetica Molecolare (INGM), Milano, Italy
⨯
Simone Fenu,

Affiliation Department of Genomics and Molecular Biology, Virology Program, Istituto Nazionale Genetica Molecolare (INGM), Milano, Italy
⨯
Reinaldo Alvarez,

Affiliation Department of Genomics and Molecular Biology, Virology Program, Istituto Nazionale Genetica Molecolare (INGM), Milano, Italy
⨯
Chiara Baruffa,

Affiliation Department of Biotechnology and Biosciences, University of Milano Bicocca, Milano, Italy
⨯
Francesco Peri,

Affiliation Department of Biotechnology and Biosciences, University of Milano Bicocca, Milano, Italy
⨯
Massimiliano Pagani,

Affiliation Department of Genomics and Molecular Biology, Virology Program, Istituto Nazionale Genetica Molecolare (INGM), Milano, Italy
⨯
Sergio Abrignani,

Affiliation Department of Genomics and Molecular Biology, Virology Program, Istituto Nazionale Genetica Molecolare (INGM), Milano, Italy
⨯
Petra Neddermann ,

* E-mail: neddermann@ingm.org (PN) (PN); defrancesco@ingm.org (RDF) (RD)

Affiliation Department of Genomics and Molecular Biology, Virology Program, Istituto Nazionale Genetica Molecolare (INGM), Milano, Italy
⨯
Raffaele De Francesco

* E-mail: neddermann@ingm.org (PN) (PN); defrancesco@ingm.org (RDF) (RD)

Affiliation Department of Genomics and Molecular Biology, Virology Program, Istituto Nazionale Genetica Molecolare (INGM), Milano, Italy
⨯

Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity

Annalisa Bianco,
Veronica Reghellin,
Lorena Donnici,
Simone Fenu,
Reinaldo Alvarez,
Chiara Baruffa,
Francesco Peri,
Massimiliano Pagani,
Sergio Abrignani,
Petra Neddermann

Published: March 8, 2012
https://doi.org/10.1371/journal.ppat.1002576

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