Progressive Visceral Leishmaniasis Is Driven by Dominant Parasite-induced STAT6 Activation and STAT6-dependent Host Arginase 1 Expression

E. Yaneth Osorio; Weiguo Zhao; Claudia Espitia; Omar Saldarriaga; Leo Hawel; Craig V. Byus; Bruno L. Travi; Peter C. Melby

doi:10.1371/journal.ppat.1002417

Loading metrics

Open Access

Peer-reviewed

Research Article

Progressive Visceral Leishmaniasis Is Driven by Dominant Parasite-induced STAT6 Activation and STAT6-dependent Host Arginase 1 Expression

E. Yaneth Osorio,

Current address: Center for Tropical Diseases, Departments of Internal Medicine, Microbiology and Immunology, and Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

Affiliations Research Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, San Antonio, Texas, United States of America, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Weiguo Zhao,

Affiliations Research Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, San Antonio, Texas, United States of America, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Claudia Espitia,

Affiliations Research Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, San Antonio, Texas, United States of America, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Omar Saldarriaga,

Current address: Center for Tropical Diseases, Departments of Internal Medicine, Microbiology and Immunology, and Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

Affiliations Research Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, San Antonio, Texas, United States of America, Department of Microbiology and Immunology, The University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Leo Hawel,

Affiliation Division of Biomedical Sciences, University of California, Riverside, California, United States of America
⨯
Craig V. Byus,

Affiliation Division of Biomedical Sciences, University of California, Riverside, California, United States of America
⨯
Bruno L. Travi,

Current address: Center for Tropical Diseases, Departments of Internal Medicine, Microbiology and Immunology, and Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

Affiliations Research Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, San Antonio, Texas, United States of America, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Peter C. Melby

* E-mail: melby@uthscsa.edu

Current address: Center for Tropical Diseases, Departments of Internal Medicine, Microbiology and Immunology, and Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

Affiliations Research Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, San Antonio, Texas, United States of America, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas, United States of America, Department of Microbiology and Immunology, The University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯

Progressive Visceral Leishmaniasis Is Driven by Dominant Parasite-induced STAT6 Activation and STAT6-dependent Host Arginase 1 Expression

E. Yaneth Osorio,
Weiguo Zhao,
Claudia Espitia,
Omar Saldarriaga,
Leo Hawel,
Craig V. Byus,
Bruno L. Travi,
Peter C. Melby

Published: January 19, 2012
https://doi.org/10.1371/journal.ppat.1002417

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hamsters
Is the Subject Area "Hamsters" applicable to this article?

Thanks for your feedback.
Parasitic diseases
Is the Subject Area "Parasitic diseases" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Leishmania donovani
Is the Subject Area "Leishmania donovani" applicable to this article?

Thanks for your feedback.
Parasite replication
Is the Subject Area "Parasite replication" applicable to this article?

Thanks for your feedback.
Spleen
Is the Subject Area "Spleen" applicable to this article?

Thanks for your feedback.
BHK cells
Is the Subject Area "BHK cells" applicable to this article?

Thanks for your feedback.
Leishmaniasis
Is the Subject Area "Leishmaniasis" applicable to this article?

Thanks for your feedback.