A Gammaherpesvirus Cooperates with Interferon-alpha/beta-Induced IRF2 to Halt Viral Replication, Control Reactivation, and Minimize Host Lethality

Pratyusha Mandal; Bridgette E. Krueger; Darby Oldenburg; Katherine A. Andry; R. Suzanne Beard; Douglas W. White; Erik S. Barton

doi:10.1371/journal.ppat.1002371

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Research Article

A Gammaherpesvirus Cooperates with Interferon-alpha/beta-Induced IRF2 to Halt Viral Replication, Control Reactivation, and Minimize Host Lethality

Pratyusha Mandal,

Affiliations Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America, Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
⨯
Bridgette E. Krueger,

Affiliation Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
⨯
Darby Oldenburg,

Affiliations Department of Health Professions, University of Wisconsin La Crosse, La Crosse, Wisconsin, United States of America, Rheumatology Research Laboratory, Gundersen Lutheran Medical Center, La Crosse, Wisconsin, United States of America
⨯
Katherine A. Andry,

Affiliation Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
⨯
R. Suzanne Beard,

Affiliations Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America, Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
⨯
Douglas W. White,

Affiliations Rheumatology Research Laboratory, Gundersen Lutheran Medical Center, La Crosse, Wisconsin, United States of America, Department of Microbiology, University of Wisconsin La Crosse, La Crosse, Wisconsin, United States of America
⨯
Erik S. Barton

* E-mail: ebarton@wakehealth.edu

Affiliations Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America, Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
⨯

A Gammaherpesvirus Cooperates with Interferon-alpha/beta-Induced IRF2 to Halt Viral Replication, Control Reactivation, and Minimize Host Lethality

Pratyusha Mandal,
Bridgette E. Krueger,
Darby Oldenburg,
Katherine A. Andry,
R. Suzanne Beard,
Douglas W. White,
Erik S. Barton

Published: November 17, 2011
https://doi.org/10.1371/journal.ppat.1002371

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