Structure of Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor Nectin-1

Paolo Di Giovine; Ethan C. Settembre; Arjun K. Bhargava; Micah A. Luftig; Huan Lou; Gary H. Cohen; Roselyn J. Eisenberg; Claude Krummenacher; Andrea Carfi

doi:10.1371/journal.ppat.1002277

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Open Access

Peer-reviewed

Research Article

Structure of Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor Nectin-1

Paolo Di Giovine ,

Contributed equally to this work with: Paolo Di Giovine, Ethan C. Settembre

Affiliation Department of Biochemistry and Molecular Biology, IRBM P. Angeletti, Pomezia, Rome, Italy
⨯
Ethan C. Settembre ,

Contributed equally to this work with: Paolo Di Giovine, Ethan C. Settembre

Affiliation Protein Biochemistry, Novartis Vaccine and Diagnostics, Cambridge, Massachusetts, United States of America
⨯
Arjun K. Bhargava,

Affiliation Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Micah A. Luftig,

Current address: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

Affiliation Department of Biochemistry and Molecular Biology, IRBM P. Angeletti, Pomezia, Rome, Italy
⨯
Huan Lou,

Affiliation Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Gary H. Cohen,

Affiliation Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Roselyn J. Eisenberg,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Claude Krummenacher ,

* E-mail: ckrummen@dental.upenn.edu (CK); andrea.carfi@novartis.com (AC)

Affiliation Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Andrea Carfi

* E-mail: ckrummen@dental.upenn.edu (CK); andrea.carfi@novartis.com (AC)

Current address: Protein Biochemistry, Novartis Vaccine & Diagnostics, Cambridge, Massachusetts, United States of America

Affiliation Department of Biochemistry and Molecular Biology, IRBM P. Angeletti, Pomezia, Rome, Italy
⨯

Structure of Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor Nectin-1

Paolo Di Giovine,
Ethan C. Settembre,
Arjun K. Bhargava,
Micah A. Luftig,
Huan Lou,
Gary H. Cohen,
Roselyn J. Eisenberg,
Claude Krummenacher,
Andrea Carfi

Published: September 29, 2011
https://doi.org/10.1371/journal.ppat.1002277

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Crystal structure
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