Exhausted CD8 T Cells Downregulate the IL-18 Receptor and Become Unresponsive to Inflammatory Cytokines and Bacterial Co-infections

Open Access

Peer-reviewed

Research Article

Jennifer T. Ingram,

Affiliations Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
John S. Yi,

Current address: Division of Surgical Science, Duke University Medical Center, Durham, North Carolina, United States of America.

Affiliation Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Allan J. Zajac

* E-mail: azajac@uab.edu

Affiliation Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯

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T cells
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Cytotoxic T cells
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Cytokines
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Opportunistic infections
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CD coreceptors
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Immune response
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Co-infections
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Inflammation
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