Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid – Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs

Selvakumar Subbian; Liana Tsenova; Paul O'Brien; Guibin Yang; Mi-Sun Koo; Blas Peixoto; Dorothy Fallows; Veronique Dartois; George Muller; Gilla Kaplan

doi:10.1371/journal.ppat.1002262

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Peer-reviewed

Research Article

Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid – Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs

Selvakumar Subbian,

Affiliation Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America
⨯
Liana Tsenova,

Affiliations Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America, Biological Sciences Department, New York City College of Technology, Brooklyn, New York, United States of America
⨯
Paul O'Brien,

Affiliation Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America
⨯
Guibin Yang,

Affiliation Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America
⨯
Mi-Sun Koo,

Affiliation Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America
⨯
Blas Peixoto,

Affiliation Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America
⨯
Dorothy Fallows,

Affiliation Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America
⨯
Veronique Dartois,

Affiliation Novartis Institute for Tropical Diseases, Singapore
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George Muller,

Affiliation Celgene Corporation, Summit, New Jersey, United States of America
⨯
Gilla Kaplan

* E-mail: kaplangi@umdnj.edu

Affiliation Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America
⨯

Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid – Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs

Selvakumar Subbian,
Liana Tsenova,
Paul O'Brien,
Guibin Yang,
Mi-Sun Koo,
Blas Peixoto,
Dorothy Fallows,
Veronique Dartois,
George Muller,
Gilla Kaplan

Published: September 15, 2011
https://doi.org/10.1371/journal.ppat.1002262

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Mycobacterium tuberculosis
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Gene expression
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