Protease-Sensitive Conformers in Broad Spectrum of Distinct PrP^Sc Structures in Sporadic Creutzfeldt-Jakob Disease Are Indicator of Progression Rate

• Chae Kim,

  Affiliations Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, National Prion Disease Pathology Surveillance Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Tracy Haldiman,

  Affiliation Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Yvonne Cohen,

  Affiliations Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, National Prion Disease Pathology Surveillance Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Wei Chen,

  Affiliations Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, National Prion Disease Pathology Surveillance Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Janis Blevins,

  Affiliations Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, National Prion Disease Pathology Surveillance Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Man-Sun Sy,

  Affiliation Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Mark Cohen,

  Affiliations Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, National Prion Disease Pathology Surveillance Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Jiri G. Safar

  * E-mail: jiri.safar@case.edu

  Affiliations Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, National Prion Disease Pathology Surveillance Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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