Impairment of Immunoproteasome Function by β5i/LMP7 Subunit Deficiency Results in Severe Enterovirus Myocarditis

Elisa Opitz; Annett Koch; Karin Klingel; Frank Schmidt; Stefan Prokop; Anna Rahnefeld; Martina Sauter; Frank L. Heppner; Uwe Völker; Reinhard Kandolf; Ulrike Kuckelkorn; Karl Stangl; Elke Krüger; Peter M. Kloetzel; Antje Voigt

doi:10.1371/journal.ppat.1002233

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Open Access

Peer-reviewed

Research Article

Impairment of Immunoproteasome Function by β5i/LMP7 Subunit Deficiency Results in Severe Enterovirus Myocarditis

Elisa Opitz,

Affiliation Medizinische Klinik für Kardiologie, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯
Annett Koch,

Affiliation Institut für Biochemie, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯
Karin Klingel,

Affiliation Abteilung Molekulare Pathologie, Institut für Pathologie und Neuropathologie, Eberhard-Karls-Universität, Tuebingen, Germany
⨯
Frank Schmidt,

Affiliation Interfakultäres Institut für Genetik und Funktionelle Genomforschung, Ernst-Moritz-Arndt-Universität, Greifswald, Germany
⨯
Stefan Prokop,

Affiliation Institut für Neuropathologie, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯
Anna Rahnefeld,

Affiliation Medizinische Klinik für Kardiologie, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯
Martina Sauter,

Affiliation Abteilung Molekulare Pathologie, Institut für Pathologie und Neuropathologie, Eberhard-Karls-Universität, Tuebingen, Germany
⨯
Frank L. Heppner,

Affiliation Institut für Neuropathologie, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯
Uwe Völker,

Affiliation Interfakultäres Institut für Genetik und Funktionelle Genomforschung, Ernst-Moritz-Arndt-Universität, Greifswald, Germany
⨯
Reinhard Kandolf,

Affiliation Abteilung Molekulare Pathologie, Institut für Pathologie und Neuropathologie, Eberhard-Karls-Universität, Tuebingen, Germany
⨯
Ulrike Kuckelkorn,

Affiliation Institut für Biochemie, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯
Karl Stangl,

Affiliation Medizinische Klinik für Kardiologie, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯
Elke Krüger,

Affiliation Institut für Biochemie, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯
Peter M. Kloetzel ,

* E-mail: p-m.kloetzel@charite.de

Affiliation Institut für Biochemie, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯
Antje Voigt

Affiliation Medizinische Klinik für Kardiologie, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯

Impairment of Immunoproteasome Function by β5i/LMP7 Subunit Deficiency Results in Severe Enterovirus Myocarditis

Elisa Opitz,
Annett Koch,
Karin Klingel,
Frank Schmidt,
Stefan Prokop,
Anna Rahnefeld,
Martina Sauter,
Frank L. Heppner,
Uwe Völker,
Reinhard Kandolf

Published: September 1, 2011
https://doi.org/10.1371/journal.ppat.1002233

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