Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies

• Ben-Jiang Ma,

  Affiliation Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America

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• S. Munir Alam,

  Affiliations Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America

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• Eden P. Go,

  Affiliation Department of Chemistry, University of Kansas, Lawrence, Kansas, United States of America

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• Xiaozhi Lu,

  Affiliation Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America

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• Heather Desaire,

  Affiliation Department of Chemistry, University of Kansas, Lawrence, Kansas, United States of America

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• Georgia D. Tomaras,

  Affiliations Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America, Deparment of Surgery, Duke University School of Medicine, Durham, North Carolina, United States of America

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• Cindy Bowman,

  Affiliation Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America

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• Laura L. Sutherland,

  Affiliation Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America

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• Richard M. Scearce,

  Affiliation Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America

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• Sampa Santra,

  Affiliation Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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• Norman L. Letvin,

  Affiliation Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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• Thomas B. Kepler,

  Affiliation Center for Computational Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America

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• Hua-Xin Liao ,

  Contributed equally to this work with: Hua-Xin Liao, Barton F. Haynes

  * E-mail: hliao@duke.edu (H-XL); hayne002@mc.duke.edu (BFH)

  Affiliations Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America

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• Barton F. Haynes

  Contributed equally to this work with: Hua-Xin Liao, Barton F. Haynes

  * E-mail: hliao@duke.edu (H-XL); hayne002@mc.duke.edu (BFH)

  Affiliations Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America

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