Functional Cure of SIVagm Infection in Rhesus Macaques Results in Complete Recovery of CD4+ T Cells and Is Reverted by CD8+ Cell Depletion

Ivona Pandrea; Thaidra Gaufin; Rajeev Gautam; Jan Kristoff; Daniel Mandell; David Montefiori; Brandon F. Keele; Ruy M. Ribeiro; Ronald S. Veazey; Cristian Apetrei

doi:10.1371/journal.ppat.1002170

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Peer-reviewed

Research Article

Functional Cure of SIVagm Infection in Rhesus Macaques Results in Complete Recovery of CD4⁺ T Cells and Is Reverted by CD8⁺ Cell Depletion

Ivona Pandrea,

Affiliations Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, United States of America, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Thaidra Gaufin,

Affiliation Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
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Rajeev Gautam,

Affiliation Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
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Jan Kristoff,

Affiliation Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Daniel Mandell,

Affiliation Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
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David Montefiori,

Affiliation Department of Surgery, Duke University, Durham, North Carolina, United States of America
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Brandon F. Keele,

Affiliation SAIC Frederick, Inc, NCI, NIH, Frederick, Maryland, United States of America
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Ruy M. Ribeiro,

Affiliation Los Alamos National Laboratory, Los Alamos New Mexico, United States of America
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Ronald S. Veazey,

Affiliation Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
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Cristian Apetrei

* E-mail: apetreic@cvr.pitt.edu

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, United States of America, Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯

Functional Cure of SIVagm Infection in Rhesus Macaques Results in Complete Recovery of CD4⁺ T Cells and Is Reverted by CD8⁺ Cell Depletion

Ivona Pandrea,
Thaidra Gaufin,
Rajeev Gautam,
Jan Kristoff,
Daniel Mandell,
David Montefiori,
Brandon F. Keele,
Ruy M. Ribeiro,
Ronald S. Veazey,
Cristian Apetrei

Published: August 4, 2011
https://doi.org/10.1371/journal.ppat.1002170

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T cells
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SIV
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